Bequinostatin A (Glutathione S-Transferase (GST) π Class Inhibitor)
Bequinostatin A <Glutathione S-Transferase (GST) π Class Inhibitor>
Cat No: FNK-14681
Size: 1 mg
Specifications
Code No. : 14681
CAS# : 151013-37-5
Molecular Formula : C28H24O9
Molecular Weight : 504.491
Source : Streptomyces sp. MI384-DF12
Supplied as : Powder
Purity : > 75% (HPLC) (contains about 20% bequinostatin C)
Long Term Storage : at - 20 °C
Solubility : Soluble in DMSO, MeOH, Pyridine Insoluble in H2O
Application Notes
Bequinostatin A is isolated from the culture broth of Streptomyces sp. MI384-DF12, and it has a significant inhibitory activity against human pi class glutathione S-transferase (GSTπ) expressed in carcinogenesis (IC50 value is 4.6 μg / mL). 1) It exhibits no toxicity after intraperitoneal injection in mice at a dose of 100 mg/kg. 1) The absolute stereochemistry of the hydroxyl group was determined by the X-ray diffraction analysis. 2) Note: Bequinostatin A seems to change to bequinostatin C slowly in the solution condition. The stock solution should be stored at 4 °C or lower, and should be used within a couple of days.
References
1) Bequinostatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384- DF12. Production, isolation, structure determination and biological activities. Aoyama T, et al. J Antibiot. 1993 46(6) 914-920. 2) The crystal structure data was deposited to the Cambridge crystallographic data centre as CCDC number 2009768.
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