Dopastin (Inhibitor for dopamine β-hydroxylase)
Product#: FNK-00381
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Dopastin (Inhibitor for dopamine β-hydroxylase)
Specification
| Code No. |
FNK-00381
|
| CAS# |
37134-80-8
|
| Molecular Formula |
C9H17N3O3
|
| Molecular Weight |
215.253
|
| Source Pseudomonas No. |
Pseudomonas No. BAC-125
|
| Appearance |
Colorless needle crystals
|
| Purity |
> 90%
|
| Long Term Storage |
at - 20 ˚C
|
| Solubility |
Soluble in MeOH, Butanol, Acetone, CHCl3, Alkaline water
Insoluble in water, Ethyl acetate, Ether, Hexane
|
Application Note
Dopastin produced by a Pseudomonus No.BAC-125 is a potent inhibitor of dopamine β-hydroxylase of beef adrenals, and its IC50 value is 4.7 × 10-6 M.1) Dopastin shows a significant hypotensive effect to spontaneously hypertensive rats and a phytotoxicity to barley germination.2) Structure and synthesis method is described.3) Dopastin has low toxicity (oral LD50:750 mg/kg, i.p. LD50:460 mg/kg in mice), and the intravenous injection of 250 mg/kg killed no mice.1)
Reference
1) Dopastin, an inhibitor of dopamine β-hydroxylase.Iinuma H, Takeuchi T, Kondo S, Matsuzaki M, Umezawa H, Ohno M. J. Antibiot. 1972, 25, 497-500.
2) Biochemical and biological studies on dopastin, an inhibitor of dopamine β-Hydroxylase. Iinuma H, Matsuzaki M, Nagatsu T, Takeuchi T, Umezawa H. Agr. Biol. Chem. 1974, 38, 2107-2111.
3) Structure and synthesis of dopastin, an inhibitor of dopamine β-hydroxylase. Iinuma H, Yagisawa N, Shibahara S, Suhara Y, Kondo S, Maeda K, Takeuchi T, Ohno M, Umezawa H. Agr. Biol. Chem. 1974, 38, 2099-2105.
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