Heliquinomycin
Product#: FNK-10665
$598.00
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Heliquinomycin
Cat. No. FNK-10665
Storage 4°C
Size 1.0 mg
CAS# 178182-49-5
Molecular Fourmula C33H30O17
Molecular Weight 698.5811
Source Streptomyces sp. MJ929-SF2
Appearance Red powder
Purity >80% by HPLC (254nm)
Long Term Strage 4℃
Solubility Soluble in DMSO, EtOH, CHCl3 , EtOAc Insoluble in H2O, n-hexane
Description
Heliquinomycin inhibits DNA helicase from HeLa cell in a non-competitive manner with the inhibition constant (Ki) of 6.8 mM. The topoisomerase II and I enzymes are inhibited at 30 μg/ml and 100 μg/ml of heliquinomycin, respectively.
* This product is licensed under JP patent NO.3490154
References
- Chino, M., et al., J. Antibiotics, 49, 752 - 757 (1996).
- Chino, M., et al., J. Antibiotics, 50, 143 - 146 (1997).
- Chino, M., et al., J. Antibiotics, 50, 781 - 784 (1997).
- Chino, M., et al., J. Antibiotics, 51, 480 - 486 (1998).
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physicochemical properties and biological activities. M. Chino; K. Nishikawa; M. Umekita; C. Hayashi; T. Yamazaki; T. Tsuchida; T. Sawa; M. Hamada; T. Takeuchi, J. Antibiotics 1996,49, 752-757
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 II. Structure determination of heliquinomycin. M. Chino; K. Nishikawa; T. Tsuchida; R. Sawa; H. Nakamura; K. S. Nakamura; Y. Muraoka; D. Ikeda; H. Naganawa; T. Sawa; T. Takeuchi, J. Antibiotics, 1997, 50, 143-146
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2. III. Biosynthesis. M. Chino; K. Nishikawa; R. Sawa; M. Hamada; H. Naganawa; T. Sawa; T. Takeuchi, J. Antibiotics,781-784
- Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. M. Chino; K. Nishikawa; A. Yamada; M. Ohsono; T. Sawa; F. Hanaoka; M. Ishizuka; T. Takeuchi, J. Antibiotics, 1998, 51, 480-486
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