Heliquinomycin

Heliquinomycin

Cat. No. FNK-10665
Storage 4°C
Size 1.0 mg
CAS#  178182-49-5
Molecular Fourmula C33H30O17
Molecular Weight 698.5811
Source Streptomyces sp. MJ929-SF2
Appearance Red powder
Purity  >80% by HPLC (254nm)
Long Term Strage 4℃
Solubility Soluble in DMSO, EtOH, CHCl3 , EtOAc Insoluble in H2O, n-hexane

Description

Heliquinomycin inhibits DNA helicase from HeLa cell in a non-competitive manner with the inhibition constant (Ki) of 6.8 mM. The topoisomerase II and I enzymes are inhibited at 30 μg/ml and 100 μg/ml of heliquinomycin, respectively. 

* This product is licensed under JP patent NO.3490154

References

1. Chino, M., et al., J. Antibiotics, 49, 752 - 757 (1996).
2. Chino, M., et al., J. Antibiotics, 50, 143 - 146 (1997).
3. Chino, M., et al., J. Antibiotics, 50, 781 - 784 (1997).
4. Chino, M., et al., J. Antibiotics, 51, 480 - 486 (1998).
5. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physicochemical properties and biological activities. M. Chino; K. Nishikawa; M. Umekita; C. Hayashi; T. Yamazaki; T. Tsuchida; T. Sawa; M. Hamada; T. Takeuchi, J. Antibiotics 1996,49, 752-757
6. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 II. Structure determination of heliquinomycin. M. Chino; K. Nishikawa; T. Tsuchida; R. Sawa; H. Nakamura; K. S. Nakamura; Y. Muraoka; D. Ikeda; H. Naganawa; T. Sawa; T. Takeuchi, J. Antibiotics, 1997, 50, 143-146
7. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2. III. Biosynthesis. M. Chino; K. Nishikawa; R. Sawa; M. Hamada; H. Naganawa; T. Sawa; T. Takeuchi, J. Antibiotics,781-784
8. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. M. Chino; K. Nishikawa; A. Yamada; M. Ohsono; T. Sawa; F. Hanaoka; M. Ishizuka; T. Takeuchi, J. Antibiotics, 1998, 51, 480-486

Enzyme Inhibitors	Name	Product Code	Link
Alkaline Phosphatase Inhibitor	Forphenicine	FNK-09636
NADH:Ubiquinone Oxidoreductase Inhibitor	Piericidin A1	FNK-14688
β-Galactosidase Inhibitor	Pyridindolol	FNK-00372
Glyoxylase Ⅰ (GloⅠ) Inhibitor	COTC	FNK-14675
α-Glucosidase Inhibitor	6-O-Methylreticulol	FNK-14693
Glutathione S-Transferase (GST) Inhibitor	Benastatin A	FNK-00379
	Benastatin B	FNK-14653
	Benastatin C	FNK-00380
Glutathione S-Transferase (GST) π Class Inhibitor	Bequinostatin A	FNK-14681
	Bequinostatin C	FNK-14654
GRP78 Up-regulation suppressor	Piericidin A1	FNK-14688
GMP synthase Inhibitor	Oxanosine	FNK-00762
Human Dipeptidyl Aminopeptidase Ⅱ Inhibitor	Dioctatin A (HCl)	FNK-14700
Dipeptidyl Peptidase Ⅲ (DPP-Ⅲ) Inhibitor	Fluostatin B	FNK-14683
Protein Phosphatase 2A (PP2A) Inhibitor	Cytostatin (Na Salt)	FNK-10664
	Rubratoxin A	FNK-10663
Thymidylate Synthase Inhibitor	Vanoxonin	FNK-10744
Receptor Tyrosine Kinase Inhibitor	Erbstatin	FNK-14697
DNA Helicase Inhibitor	Heliquinomycin	FNK-10665	Current Link
Dopamine β-Hydroxylase Inhibitor	Dopastin	FNK-00381
Trehalase Resistant Trehalose Analogue	Lentztrehalose A	FNK-14678
	Lentztrehalose B	FNK-14679
	Lentztrehalose C	FNK-14680
Nucleoside Diphosphate Kinase (NDPK) Inhibitor	Cyclamidomycin	FNK-01541
Heparanase Inhibitor	Heparastatin<SF4>(HCl)	FNK-11829