Rubratoxin A

Description

Rubratoxin A is a mycotoxin produced by Penicillium. While this compound inhibits protein phosphatase 2A (PP2A) in a competitive manner with the inhibition constant (Ki) of 28.7 nM (IC50= 6.1-15.1 nM) , it does not inhibit protein phosphatase 1, protein phosphatase 2B, protein tyrosine phosphatase 1B, alkaline phosphatase, and calf intestine phosphatase(CIP) up to 200 µM. Rubratoxin A shows cytotoxicity in cultured mammalian cells with IC50 values of around 15 µM and induces overphosphorylation of PP2A substrate proteins.

Application Notes
 

Rubratoxin A is a mycotoxin produced by Penicillium sp While this compound inhibits PP 2 A (p roteinphosphatase 2 A) in a competitive manner with the inhibition constant Ki of 28 7 nM (IC 50 6 1 15 1nM it does not inhibit PP 1 (p rotein p hosphatase 1 PP 2 B (p rotein p hosphatase 2 B PTP 1 B (proteint yrosine p hosphatase 1 B) and CIP (a lkaline p hosphatase, c alf i ntestine) up to 200 μ M Rubratoxin A shows cytotoxicity in cultured mammalian cells with IC 50 values of around 15 μ M and induces overphosphorylation in PP 2 A substrate proteins.

Reference

1. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis.
   Wada S,et al. Cancer Sci. 2010 101(3) 743-50

Enzyme Inhibitors	Name	Product Code	Link
Alkaline Phosphatase Inhibitor	Forphenicine	FNK-09636
NADH:Ubiquinone Oxidoreductase Inhibitor	Piericidin A1	FNK-14688
β-Galactosidase Inhibitor	Pyridindolol	FNK-00372
Glyoxylase Ⅰ (GloⅠ) Inhibitor	COTC	FNK-14675
α-Glucosidase Inhibitor	6-O-Methylreticulol	FNK-14693
Glutathione S-Transferase (GST) Inhibitor	Benastatin A	FNK-00379
	Benastatin B	FNK-14653
	Benastatin C	FNK-00380
Glutathione S-Transferase (GST) π Class Inhibitor	Bequinostatin A	FNK-14681
	Bequinostatin C	FNK-14654
GRP78 Up-regulation suppressor	Piericidin A1	FNK-14688
GMP synthase Inhibitor	Oxanosine	FNK-00762
Human Dipeptidyl Aminopeptidase Ⅱ Inhibitor	Dioctatin A (HCl)	FNK-14700
Dipeptidyl Peptidase Ⅲ (DPP-Ⅲ) Inhibitor	Fluostatin B	FNK-14683
Protein Phosphatase 2A (PP2A) Inhibitor	Cytostatin (Na Salt)	FNK-10664
	Rubratoxin A	FNK-10663	Current Link
Thymidylate Synthase Inhibitor	Vanoxonin	FNK-10744
Receptor Tyrosine Kinase Inhibitor	Erbstatin	FNK-14697
DNA Helicase Inhibitor	Heliquinomycin	FNK-10665
Dopamine β-Hydroxylase Inhibitor	Dopastin	FNK-00381
Trehalase Resistant Trehalose Analogue	Lentztrehalose A	FNK-14678
	Lentztrehalose B	FNK-14679
	Lentztrehalose C	FNK-14680
Nucleoside Diphosphate Kinase (NDPK) Inhibitor	Cyclamidomycin	FNK-01541
Heparanase Inhibitor	Heparastatin<SF4>(HCl)	FNK-11829

Structural classification	Compound Name	Chemical Structure			Property / Biological activity			Link
Bacterial proteins/Inhibition of DNA synthesis	Aplasmomycin (Sodium Salt)				Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei.
	Migrastatin				Migrastatin inhibited metastasis of human esophageal cancer cells and anchorage-independent growth of human small cell lung carcinoma cells.
Macrolactams	Bisucaberin				Bisucaberin is a siderophore with iron-affinity and induced concentration dependent macrophage-mediated tumor cell lysis.
Cyclic peptides	Bottromycin A2				Bottromycin A2 showed growth inhibitory activity against gram-positive bacteria, MRSA (Methicillin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci).
	Iturin A-2				Iturin A-2 showed the control of damping-off of tomato (a seedling disease) and cytotoxicity to human breast cancer cell line BT-474.
	Plipastatin A1				Plipastatin A1 inhibited phospholipase A2 and induced ISR (induced-systemic-resistance).
	Phepropeptin A				Phepropeptin A inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin B				Phepropeptin B inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin C				Phepropeptin C inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin D				Phepropeptin D inhibited proteasomal chymotrypsin-like activity.
Cycloalkenes	Rubratoxin A				Rubratoxin A inhibited protein phosphatase 2A (PP2A) in a competitive manner.			Current Link