Pyridindolol (Inhibitor for β-galactosidase)

Product#: 00372
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Pyridindolol (Inhibitor for β-galactosidase)


Cat No: 00372
Size: 1 mg
Storage:  - 20 ˚C

 
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Specifications
 
Code No. 00372
CAS# 55812-46-9
Molecular Formula C14H14N2O3
Molecular Weight 258.277
Source Streptomyces alboverticilliatus MD401-C5
Appearance White crystals
Purity > 90% (HPLC)
Long Term Storage at - 20 ˚C
Solubility Soluble in MeOH, EtOH, n-BuOH, DMSO, DMF, 0.5M-HCl.
Slightly soluble in H2O.
Insoluble in Benzene, CHCl3 and Ethyl ether.
 

Application Note

Pyridindolol has inhibitory activity against neutral bovine liver β-galactosidase which has optimal activity at pH 5.0 in tris acetate buffer. The IC50 value is 7.4 ×10-6 M at pH 4.5.3) However, it shows weak activity against the enzyme in the neutral condition.3) Pyridindolol shows no antibacterial and antifungal activity at 100 μg/ml and has low toxicity (LD50 >500 mg/kg, intraperitoneal injection) to mice.1)


References

1) Pyridindolol, a new β-galactosidase inhibitor produced by actinomycetes. Aoyagi T, Kumagai M, Hazato T, Hamada M, Takeuchi T, Umezawa H. J. Antibiot. 1975, 28, 558-560.
2) The structures of pyridindolol, inhibitor of β-galactosidase. Kumagai M, Naganawa H, Aoyagi T, Umezawa H, Nakamura H, Iitaka Y. J. Antibiot. 1975, 28, 876-880. 
3) Inhibitory activity of pyridindolol on β- galactosidase. Kumagai M, Aoyagi T, Umezawa H. J. Antibiot. 1976, 29, 696-703.

 
 
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