Pyridindolol (Inhibitor for β-galactosidase)
Product#: FNK-00372
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Pyridindolol (Inhibitor for β-galactosidase)
Cat No: FNK-00372
Size: 1 mg
Storage: - 20 ˚C
Specifications
| Code No. | 00372 |
| CAS# | 55812-46-9 |
| Molecular Formula | C14H14N2O3 |
| Molecular Weight | 258.277 |
| Source | Streptomyces alboverticilliatus MD401-C5 |
| Appearance | White crystals |
| Purity | > 90% (HPLC) |
| Long Term Storage | at - 20 ˚C |
| Solubility | Soluble in MeOH, EtOH, n-BuOH, DMSO, DMF, 0.5M-HCl. Slightly soluble in H2O. Insoluble in Benzene, CHCl3 and Ethyl ether. |
Application Note
Pyridindolol has inhibitory activity against neutral bovine liver β-galactosidase which has optimal activity at pH 5.0 in tris acetate buffer. The IC50 value is 7.4 ×10-6 M at pH 4.5.3) However, it shows weak activity against the enzyme in the neutral condition.3) Pyridindolol shows no antibacterial and antifungal activity at 100 μg/ml and has low toxicity (LD50 >500 mg/kg, intraperitoneal injection) to mice.1)
References
1) Pyridindolol, a new β-galactosidase inhibitor produced by actinomycetes. Aoyagi T, Kumagai M, Hazato T, Hamada M, Takeuchi T, Umezawa H. J. Antibiot. 1975, 28, 558-560.
2) The structures of pyridindolol, inhibitor of β-galactosidase. Kumagai M, Naganawa H, Aoyagi T, Umezawa H, Nakamura H, Iitaka Y. J. Antibiot. 1975, 28, 876-880.
3) Inhibitory activity of pyridindolol on β- galactosidase. Kumagai M, Aoyagi T, Umezawa H. J. Antibiot. 1976, 29, 696-703.
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