Piericidin A1, NADH:Ubiquinone Oxidoreductase Inhibitor

Cat. No.: FNK-14688

Size: 3x1mg
CAS#: 2738-64-9
Molecular Formula: C₂₅H₃₇NO₄
Molecular Weight: 415.574
Source: Streptomyces mobaraensis
Supplied as:  EtOH solution (1mg/mL)
Purity: >90 % (HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in MeOH, EtOH, Hexane, DMSO and DMF Poorly soluble in H2O
Synonyms: PiericidinA

Description

Piericidin A1 was first found as an insecticide and isolated from the fermentation broth of Streptomyces mobaraensis. Piericidin A1 is a potent inhibitor of complex I (NADH:ubiquinone oxidoreductase) that binds to its ubiquinone binding site (IC50 value is 3.7 nM). It exhibits high toxicity, and the LD50 value is 0.87 mg/kg after intraperitoneal injection in mice.It is suggested that piericidin A1 prevents up-regulation of GRP78 and exhibits cytotoxicity in glucose-deprived HT29 cells (etoposide-resistant).

Note: It is recommended a stock solution should be protected from light and use within a couple of days.

References:

1) Isolation and physiological activities of piericidinA, a natural insecticide produced by Streptomyces. Tamura S, et al. Agr Biol Chem. 1963 27(8) 576-582.
2) Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). OkunJ.G, et al. J Biol Chem. 1999 274(5) 2625-2630.
3) The unique chemistry and biology of piericidins. Zhou X. et al. J Antibiot. 2016 69(6) 582-593.
4) Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidinA, a GRP78 down-regulator.  Hwang J-H, et al. J Cell Physiol. 2008 215(1) 243-250.


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