Lentztrehalose A (Trehalase Resistant)
Product#: FNK-14678
$598.00
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Lentztrehalose A (Trehalase Resistant)
Cat No.: FNK-14678
Size: 25 mg
Specifications
Code No. : 14678 CAS# : 1609356-99-1
Molecular Formula : C17H32O13
Molecular Weight : 444.430
Source : Lentzea sp. ML457-mF8
Supplied as : Powder
Purity : >80% (qNMR)
Long Term Storage : at -20 oC
Solubility : Soluble in MeOH, DMSO, H2O Insoluble in Hexane
Molecular Formula : C17H32O13
Molecular Weight : 444.430
Source : Lentzea sp. ML457-mF8
Supplied as : Powder
Purity : >80% (qNMR)
Long Term Storage : at -20 oC
Solubility : Soluble in MeOH, DMSO, H2O Insoluble in Hexane
Outline
- Shows antitumor activity in mice bearing S-180 sarcoma and Ehrlich carcinoma cells at 12.5-50 mg/kg/day without apparent toxicity to mammalian cells.
- Shows bone reinforcement and anti-obesity effect in a postmenopausal mouse model.
- Not digested by various microbes which metabolize trehalose.
Resistant to porcine kidney trehalase.
Lentztrehalose A is a biologically stable analog of trehalose, isolated from the soilid-state culture of Lentzea sp. ML457-mF8. 1,2,3) While lentztrehalose A is resistant to porcine kidney trehalase and various microbes which degrades trehalose, 3) it shows tolehalose like bioactivities, such as bone reinforcement and anti-obesity effect in a postmenopausal mouse model. 1) Furthermore, lentztrehalose A has antitumor activity, which trehalose does not show, in mice bearing S-180 sarcoma and Ehrlich carcinoma cells at 12.5-50 mg/kg per day without apparent toxicity to mammalian cells. 1)
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Data Examples
Stable againt various bacteria and microorganisms
Lentztrehalose A, B, C or trehalose were added to the seven bacterial cultures, and the culture was incubated. Although trehalose was degraded and reduced, lentztrehaloses showed little degradation.
High stability against trehalase
Lentztrehalose A-C and trehalose were reacted with porcine kidney trehalase and the concentrations of released glucose were determined by a hexokinase assay. Lentztrehalose A-C showed no degradation and high stability against trehalose-degrading enzymes.
Concentration in mouse blood with oral administration
The blood kinetics of administered compounds are important for showing their activity in vivo. When mice were orally administered Lentztrehalose A-C, their blood levels increased significantly compared to trehalose.
Antitumor activity in tumor-bearing mice (Lentztrehalose A)
Tumor growth results in ICR mice bearing sarcoma 180 tumor cells administered orally(P.O.) or intravenous injection(I.V.) with 50 mg/kg of lentztrehalose A, trehalose or physiological saline(control) on the date indicated as above.
Life-prolonging effect in tumor-bearing mice (Lentztrehalose A)
Tumor growth results in ICR mice bearing S-180 sarcoma cells administered orally(P.O.) or intravenous injection(I.V.) at 50 mg/kg of Lentztrehalose A, Trehalose or physiological saline(control) on the date indicated as above.
References
1) Structure and biological properties of lentztrehalose: a novel trehalose analog. Wada S, et al. J Antibiot. 2014 67(4) 319-322. 2) Synthesis and determination of absolute configuration of lentztrehalose A. Zhang M, et al. Chem Pharm Bull. 2015 63(11) 961-966. 3) Stability and bioavailability of lentztrehaloses A, B, and C as replacements for trehalose. Wada S, et al. J Agric Food Chem. 2016 64(38) 7121-7126.
