Benastatin B

Product#: 14653
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Benastatin B 

Specifications

Code No.: 14653
Size: 1mg
CAS#: 138968-86-2
Molecular Formula: C30H30O7
Molecular Weight: 502563
Source: Streptomyces sp. MI384-DF12
Appearance: Brownish-yellow powder
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO. Poorly soluble in MeOH, Acetone, EtOAc. Insoluble in H2O.

Application Notes

Benastatin B is isolated from the culture broth of Streptomyces sp.MI384-DF12 as an inhibitor of glutathione S-transferase (GST).1,2 The inhibition of benastatin B against GST is competitive with 3,4-dichloronitrobenzene (Ki: 3.7×10-6M), and noncompetitive with glutathione (Ki: 4.2×10-6M). Benastatin B has activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).1

References
  1. Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. Aoyagi T, et al. J Antibiot. 1992 45(9) 1385-1390.
  2. BenastatinsA and B, new inhibitors of glutathione S-transferase, produced by Streptomycessp. MI384-DF12. II. Structure determination of benastatinsA and B. Aoyama T. et al. J Antibiot.1992 45(9) 1391-1396.
 
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