Oxanosine
Product#: FNK-00762
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Oxanosine (Inhibitor for GMP synthetase and inosine monophosphate (IMP) dehydrogenase)
Specifications
Code No.: FNK-00762
CAS#: 80394-72-5
Molecular Formula: C10H12N4O6
Molecular Weight: 284.227
Source: Streptomyces capreolus MG265-CF3
Appearance: Colorless needle crystals
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in H2O, DMSO, MeOH. Insoluble in CHCl3.
Application Notes
CAS#: 80394-72-5
Molecular Formula: C10H12N4O6
Molecular Weight: 284.227
Source: Streptomyces capreolus MG265-CF3
Appearance: Colorless needle crystals
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in H2O, DMSO, MeOH. Insoluble in CHCl3.
Oxanosine is a guanosine analog antibiotic isolated from the culture broth of Streptomyces capreolus MG265-CF3, which has antibacterial activity against Eschericia.coli K-12 and cell growth inhibitory activity against HeLa cells.1 Oxanosine is confirmed to be a competitive inhibitor of GMP synthetase and its Ki value is 7.4 x 10-4 M.2 Oxanosine (2 µg/ml) induce a reversion toward the normal phenotype of K-ras-transformed rat kidney cells by inhibiting inosine monophosphate (IMP) dehydrogenase.3 Oxanosine inhibits HIV-1 replication, its EC50 values is 7.0 µg/ml against CEM cells.4
References
- Oxanosine, a novel nucleoside from actinomycetes. Shimada N, Yagisawa N, Naganawa H, Takita T, Hamada M, Takeuchi T, Umezawa H. J. Antibiot. 1981, 34, 1216-1218.
- Mode of action of oxanosine, a novel nucleoside antibiotic, Yagisawa N, Shimada N, Takita T, Ishizuka M, Takeuchi T, Umezawa H.J. Antibiot. 1982, 35, 755-759.
- Induction by the guanosine analogue oxanosine of reversion toward the normal phenotype of K-ras-transformed rat kidney cells.
Itoh O, Kuroiwa S, Atsumi S, Umezawa K, Takeuchi T, Hori M. Cancer Res. 1989, 49, 996-1000. - Syntheses of oxanosine and carbocyclic oxanosine derivatives as anti-HIV agents. Saito Y, Nakamura M, Ohno T, Chaicharoenpong C, Ichikawa E, Yamamura S, Kato K, Umezawa K. J.Antibiot. 2000, 53, 309-313.
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