6-O-Methylreticulol (cyclic AMP Phosphodiesterase Inhibitor, α-Glucosidase Inhibitor)
Product#: FNK-14693
$598.00
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6-O-Methylreticulol (cyclic AMP Phosphodiesterase Inhibitor, α-Glucosidase Inhibitor)
Cat. No.: FNK-14693Size: 1mg
CAS#: 24350-93-4
Molecular Formula: C12H12O5
Molecular Weight: 236.223
Source: Streptomyces mobaraensis
Supplied as: Powder
Purity: >98 % (HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in MeOH, DMSO and DMF. Insoluble in H2O
Description
Along with reticulol and other isocoumarins, 6-O-methylreticulol was isolated from the fermentation broth of Streptomyces mobaraensis MD611-C6. Though it had low inhibitory activity against cAMP phosphodiesterase, it was reported lately that 6-O-methylreticulol has α-glucosidase inhibitory activity (IC50 value: 41.75 μg/ml).
References
1) Isolation and structure of new isocoumarins. FurutaniY, et al. AgrBiol Chem. 1977 41(7) 1179-1183.
2) Metabolites produced by Streptomyces mobaraensis. Lin J, et al. AgrBiol Chem. 1971 35(3) 363-369.
3) α-Glucosidase inhibitor produced by an endophytic fungus, Xylariacesesp. QGS01 from QuercusgilvaBlume. IndrianingsihA.W, et al. Food Science and Human Wellness. 2017 6(2) 88-95.
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