Cytostatin (1mg)
Cytostatin
Cat. No. FNK-10664
Storage (-20°C)
Size 1.0mg
CAS# 156856-30-3
Molecular Formula C21H32NaO7P
Molecular Weight 450.4381
Source Streptomyces sp. MJ654-NF4
Appearance Yellowish powder
Purity >75% by HPLC (254nm)
Long Term Storage at -20℃
Solubility Soluble in MeOH, DMSO, CHCl3, EtOAc, H2O Insoluble in n-Hexane
Description
Cytostatin inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. The IC50 values are 1.3 µg/ml to laminin and 1.4 µg/ml to collagen.
Cytostatin inhibits protein phosphatase 2A with an IC50 of 0.09 µg/ml in a non competitive manner against a substrate, p-nitrophenyl phosphate, but it has no apparent effect on other protein phosphatases including protein phosphatase 1, protein phosphatase 2B and alkaline phosphatase even at 100 µg/ml.
* This product is licensed under JP patent NO.367455
Reference
- Amemiya, M., et al., J. Antibiotics, 47, 536 - 540 (1994).
- Masuda, T., et al., J. Antibiotics, 48, 528 - 529 (1995).
- Kawada, M., et al., Biochim. Biophys. Acta., 1452, 209 - 217 (1999).
- Kawada, M., et al., Int. Immunopharmacol., 3, 179 - 188 (2003).
- Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produed by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities. M. Amemiya, M. Ueno, M. Osono, T. Masuda, N. Kinoshita, C. Nishida, M. Hamada, M. Ishizuka, T. Takeuchi, J Antibiotics, 1994, 47, 536-40.
- Inhibitory effect of cytostatin on spontaneous lung metastasis of B16-BL6 melanoma T. Masuda, S. Watanabe, M. Amemiya, M. Ishizuka, T. Takeuchi, J. Antibiotics, 1995, 48, 528-529
- Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. M. Kawada, M. Amemiya, M.Ishizuka, T. Takeuchi, Biochim Biophys Acta. , 1999, 1452, 209-217
- Specific inhibitors of protein phosphatase 2A inhibit tumor metastasis through augmentation of natural killer cells. M Kawada, M Kawatsu, T Masuda, S Ohba, M Amemiya, T Kohama, M Ishizuka, T Takeuchi, Int Immunopharmacol., 2003, 3, 179-188
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