Vanoxonin
Product#: FNK-10744
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Vanoxonin (Inhibitor for thymidylate synthetase)
Specifications
Code No.: FNK-10744
CAS#: 86933-99-5
Molecular Formula: C18H25N3O9
Molecular Weight: 427.41
Source: Saccharopolyspora hirusta MG245-CF2
Appearance: white powder
Purity: > 80%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in MeOH, DMSO, Acetic Acid and H2O Insoluble in Ethyl acetate, CHCl3 and n-Hexane
CAS#: 86933-99-5
Molecular Formula: C18H25N3O9
Molecular Weight: 427.41
Source: Saccharopolyspora hirusta MG245-CF2
Appearance: white powder
Purity: > 80%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in MeOH, DMSO, Acetic Acid and H2O Insoluble in Ethyl acetate, CHCl3 and n-Hexane
Application Notes
Vanoxonin is found in cultured broth of Saccharopolyspora hirsuta MG245-CF2 as an inhibitor of thymidylate synthetase.1,2 Vanoxonin forms a vanadium complex which exhibits a strong inhibition against the synthetase.1 The concentration for 50% inhibition of thymidylate synthetase is 200 µg/mL in the absence of vanadium, but 0.7 µg/mL in complex with vanoxonin-V5+ 1 The in vitro cytotoxic activity of the complex was examined against L-1210 lymphatic leukemia cells, and the minimum inhibitory concentration of the complex was 25 µg/mL.1 The structure-activity rerationship has been studied.3
References
- Vanoxonin, a new inhibitor of thymidylate synthetase. Kanai F, et al. J Antibiot. 1983 36(6) 656-660.
- Vanoxonin, a new inhibitor of thymidylate synthetase. II. Structure determination and total synthesis. Kanai F, et al. J Antibiot. 1985 38(1) 31-38.
- Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex. Kanai F, et al. J Antibiot. 1985 38(1) 39-50.
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