Dioctatin A (Hydrochloride) (Human Dipeptidyl Aminopeptidase II Inhibitor, Aflatoxin Production Inhibitor)

Cat. No.: FNK-14700

Size: 1mg
Parent CAS#: 138146-67-5 (salt free form)
Molecular Formula: C₂₁H₃₉N₃O₄ HCl
Molecular Weight: 434.018
Source: Streptomyces sp.
Supplied as: Powder, hydrochloride salt
Purity: >95% (HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in acidic DMSO, acidic water, acidic MeOH

Note: CAS number 138146-67-5 is the salt free form of dioctatin A. The dioctatin A we supply is the more soluble hydrochloride salt form of which CAS number has not been given yet.

Description:
Dioctatin A was isolated from the fermentation broth of Streptomyces sp. SA-2581 as a selective inhibitor of dipeptidyl aminopeptidase II (IC50: 0.19 μg/ml, rat pancreas). It was found that dioctatin A strongly inhibited aflatoxin production by Aspergillus parasiticus, with an IC50 value of 4.0 μM. A devinyl derivative of dioctatin A, dioctatin, also inhibited the aflatoxin production, and the target of dioctatin was identified as mitochondrial protease ClpP.

References

1) Novel aminopeptidase-inhibiting dioctatinsand their manufacture with Streptomycesspecies. Takeuchi T,et al. JpnPatent 1991 JP03077857 A1
2) Aflatoxin production inhibitor, and method for control of aflatoxin poisoning using the same. SakudaS,et al. US Patent 2010 US2010/0063150 A1
3) Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Yoshinari T,et al. Microbiology 2007 153(8) 2774-2780.
4) Dioctatin activates ClpPto degrade mitochondrial components and inhibits aflatoxin production. Furukawa T,et al.Cell Chem Biol. 2020 27(11) 1396-1409.

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