Althiomycin
Product#: FNK-14660
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Althiomycin
Specifications
Code No.: FNK-14660
CAS#: 12656-40-5
Molecular Formula: C16H17N5O6S2
Molecular Weight: 439.461
Source: Streptomyces althioticus No. 245-Z2
Appearance: White crystals
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in ethyl cellosolve, pyridine, DMSO. Poorly soluble in MeOH, EtOAc,acetone. Insoluble in H2O.
CAS#: 12656-40-5
Molecular Formula: C16H17N5O6S2
Molecular Weight: 439.461
Source: Streptomyces althioticus No. 245-Z2
Appearance: White crystals
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in ethyl cellosolve, pyridine, DMSO. Poorly soluble in MeOH, EtOAc,acetone. Insoluble in H2O.
Application Notes
Althiomycin is a sulfur containing peptide antibiotic obtained from Streptomyces althioticus No. 245-Z2.1-3 It is active against both Gram-positive and -negative bacteria such as Streptococcus pneumoniae, Bacillus anthracis, Escherichia coli and Salmonella Typhi has relatively low toxicity.1 Althiomycin inhibits protein synthesis in both intact cells and cell-free system of E. coli.4 Althiomycin inhibits the puromycin reaction without showing any inhibition against aminoacyl-tRNA synthesis and binding of aminoacyl-tRNA to ribosomes.4 Total synthesis of althiomycin and activity of its derivatives have been studied.5,6
References
- A new antibiotic, althiomycin. Yamaguchi H, et al. J Antibiot. 1957 10(5) 195-200.
- The structure of althiomycin. Sakakibara H, et al. J Antibiot. 1974 27(11) 897-899.
- The structure of althiomycin. Kirst H A, et al. J Antibiot. 1975 28(4) 286-291.
- Studies on the mode of action of althiomycin. Fujimoto H, et al. J Antibiot. 1970 23(6) 271-275.
- Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. Zarantonello P, et al. Bioorg Med Chem Lett. 2002 12(4) 561-565.
- Total synthesis of antibiotic althiomycin. Inami K, et al. Bull Chem Soc Jpn. 1985 58(1) 352-360.
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