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Phepropeptin B Proteasome Inhibitor

Product#: FNK-16965

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Phepropeptin B Proteasome Inhibitor

Cat No.: FNK-16965
Size: 1mg

Specifications

Code No : 16965
CAS# : 396729-24-1
Molecular Formula : C40H56N6O6
Molecular Weight : 716.924
Source : Streptomyces sp. MK600-cF7
Appearance : Powder
Purity : > 98% (HPLC)
Long Term Storage : at - 20 °C
Solubility : Soluble in MeOH, DMSO, DMF
Insoluble in H2O

Application Notes

Phepropeptin B was isolated from cultured broth of Streptomyces sp. MK600-cF7 as an inhibitor of
proteasome (IC50 value 11.0 μg/ml).It showed no inhibition toward proteasomal trypsin-like activity
and α-chymotrypsin from bovine pancreas at 100 μg/ml.

Description
Phepropeptin B is a cyclic hexapeptide that functions as a proteasome inhibitor. It is one of four related compounds (A, B, C, and D) isolated from microbial sources and named phepropeptins.

The structure of Phepropeptin B has been determined to be cyclo(-L-Leu-D-Phe-L-Pro-L-Phe-D-Leu-L-Val-). This structure was confirmed through a combination of NMR analysis, amino acid analysis, and comparison with synthesized compounds.

As a proteasome inhibitor, Phepropeptin B specifically targets the chymotrypsin-like activity of the proteasome, which is involved in regulating many cellular functions. Importantly, it does not inhibit alpha-chymotrypsin, indicating a degree of selectivity in its inhibitory action.

Phepropeptin B is available commercially as a research tool for studying proteasome function and cellular processes. It is typically supplied with high purity (>98%) for use in biochemical and cellular assays.

References
1) Isolation and structural determination of pheptopeptins A, B, C and D, new proteasome inhibitors produced by
Streptomyces sp. Sekizawa R, et al. J Antibiot. 2001 54(11) 874-881.

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Enzyme Inhibitors	Compound Name	Product Code	Link
Serine carboxypeptidase inhibitor	Belactin A	FNK-17736
Tyrosine hydroxylase inhibitor	Oudenone (Potassium Salt)	FNK-16640
Proteasome inhibitor	Phepropeptin A	FNK-16964
	Phepropeptin B	FNK-16965	Current Link
	Phepropeptin C	FNK-16966
	Phepropeptin D	FNK-16967
Angiotensin-converting enzyme (ACE) inhibitor	Foroxymithine	FNK-16968
Biological Activity on Cells and Organisms	Compound Name	Product Code	Link
Inhibition of NO production in macrophage	SF2425 (Sulfate)	FNK-17577
Antitumor effect/Cytotoxicity/Anti-angiogenesis	Bactobolin A (Hydrochloride)	FNK-08465
	Clazamycin A (Hydrochloride)	FNK-16715
	Lavendamycin	FNK-16734
	MC-1	FNK-16479
Immunomodulation/Immunosuppressant effect	Bactobolamine	FNK-15160
Immunomodulation/Immunosuppressant effect	Conagenin	FNK-16969
Siderophore	Foroxymithine	FNK-16968
Antihypertensive effect	Oudenone (Potassium Salt)	FNK-16640
Infectious Disease Prevention	Compound Name	Product Code	Link
Antibacterial activity/Antifungal activity	SF2425 (Sulfate)	FNK-17577
Antibacterial activity/Antifungal activity	Lavendamycin	FNK-16734
Antimalarial	Aplasmomycin (Sodium Salt)	FNK-17683
Bacterial proteins/Inhibition of DNA synthesis	Actinobolin (Sulfate)	FNK-15172
Bacterial proteins/Inhibition of DNA synthesis	Clazamycin A (Hydrochloride)	FNK-16715

Natural macrocyclic compounds from microorganisms:

Structural classification	Compound Name	Property / Biological activity	Link
Bacterial proteins/Inhibition of DNA synthesis	Aplasmomycin (Sodium Salt)	Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei.
Bacterial proteins/Inhibition of DNA synthesis	Migrastatin	Migrastatin inhibited metastasis of human esophageal cancer cells and anchorage-independent growth of human small cell lung carcinoma cells.
Macrolactams	Bisucaberin	Bisucaberin is a siderophore with iron-affinity and induced concentration dependent macrophage-mediated tumor cell lysis.
Cyclic peptides	Bottromycin A2	Bottromycin A2 showed growth inhibitory activity against gram-positive bacteria, MRSA (Methicillin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci).
	Iturin A-2	Iturin A-2 showed the control of damping-off of tomato (a seedling disease) and cytotoxicity to human breast cancer cell line BT-474.
	Plipastatin A1	Plipastatin A1 inhibited phospholipase A2 and induced ISR (induced-systemic-resistance).
	Phepropeptin A	Phepropeptin A inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin B	Phepropeptin B inhibited proteasomal chymotrypsin-like activity.	Current Link
	Phepropeptin C	Phepropeptin C inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin D	Phepropeptin D inhibited proteasomal chymotrypsin-like activity.
Cycloalkenes	Rubratoxin A	Rubratoxin A inhibited protein phosphatase 2A (PP2A) in a competitive manner.