Bottromycin A2

Bottromycin A2
(Inhibitor for protein synthesis)


Specifications

• Code No. : FNK-00592
• Size: 1 mg
• CAS# : 15005-62-6
• Molecular Formula : C₄₂H₆₂N₈O₇S
• Molecular Weight : 823.067
• Source : Streptomyces, No. 3668-L2
• Appearance : white powder
• Purity : >80% (HPLC)
• Shipping conditions: Room Temperature
• Long Term Storage : at - 20 °C
• Solubility : Soluble in MeOH, Ether and H₂O Insoluble in n-Hexane

1. Structures of bottromycins A and B. Nakamura S, Chikaike T, Yonehara H, Umezawa H. J. Antibiot. 1965, 18, 60-61.
2. Isolation and characterization of bottromycin A and B. Nakamura S, Chikaike T, Karasawa K, Tanaka N, Yonehara H, Umezawa H. J. Antibiot. 1965, 18, 47-52.
3. Structure determination and total synthesis of bottromycin A2: a potent antibiotic against MRSA and VRE. Shimamura H, Gouda H, Nagai K, Hirose T, Ichioka M, Furuya Y, Kobayashi Y, Hirono S, Sunazuka T, Omura S. Angew Chem int Ed Engl. 2009, 48, 914-917.
4. Mechanism of protein synthesis inhibition by bottromycin A2: studies with puromycin. Lin YC, Kinoshita T, Tanaka N. J. Antibiot. 1968, 21, 471-476.
5. Mode of action of bottromycin A2. Release of aminoacyl- or peptidyl-tRNA from ribosomes. Otaka, T. & A. Kaji J. Biol. Chem. 1976, 251, 2299–2306.

Infection Related	Name	Product Code	Link
Anti-HIV-Ⅰ	Benanomicin A	FNK-02966
	Benanomicin B	FNK-02968
Anti-MRSA, Anti-VRE	Bottromycin A2	FNK-00592	Current Link
Anti-Gram Positive / Negative Bacteria	Althiomycin	FNK-14660
	Cyclamidomycin	FNK-01541
	Negamycin (HCl)	FNK-14662
Anti-Gram Positive Bacteria	Bottromycin A2	FNK-00592	Current Link
Anti-Respiratory Infectious Bacteria	Forphenicinol	FNK-09637
Acid-Fast Bacillus Growth Suppression	Minosaminomycin	FNK-02872
Antifungal	Benanomicin A	FNK-02966
	Benanomicin B	FNK-02968
Bacterial Protein Synthesis Inhibitor	Althiomycin	FNK-14660
	Minosaminomycin	FNK-02872
	Negamycin (HCl)	FNK-14662
Pneumocystis pneumonia suppression	Benanomicin A	FNK-02966

Structural classification	Compound Name	Chemical Structure			Property / Biological activity			Link
Bacterial proteins/Inhibition of DNA synthesis	Aplasmomycin (Sodium Salt)				Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei.
	Migrastatin				Migrastatin inhibited metastasis of human esophageal cancer cells and anchorage-independent growth of human small cell lung carcinoma cells.
Macrolactams	Bisucaberin				Bisucaberin is a siderophore with iron-affinity and induced concentration dependent macrophage-mediated tumor cell lysis.
Cyclic peptides	Bottromycin A2				Bottromycin A2 showed growth inhibitory activity against gram-positive bacteria, MRSA (Methicillin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci).			Current Link
	Iturin A-2				Iturin A-2 showed the control of damping-off of tomato (a seedling disease) and cytotoxicity to human breast cancer cell line BT-474.
	Plipastatin A1				Plipastatin A1 inhibited phospholipase A2 and induced ISR (induced-systemic-resistance).
	Phepropeptin A				Phepropeptin A inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin B				Phepropeptin B inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin C				Phepropeptin C inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin D				Phepropeptin D inhibited proteasomal chymotrypsin-like activity.
Cycloalkenes	Rubratoxin A				Rubratoxin A inhibited protein phosphatase 2A (PP2A) in a competitive manner.