Aplasmomycin A (sodium salt) Insecticidal, Anti-Plasmodium Antibiotic
Product#: FNK-17683
$598.00
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Aplasmomycin A (sodium salt) Insecticidal, Anti-Plasmodium Antibiotic
Cat No.: FNK-17683Specifications:
Molecular formula: C40H60BO14Na
MW: 798.706
Purity: >98% (HPLC)
Solubility: Soluble in DMSO and methanol, practically insoluble in water.
Storage conditions: -20℃
Application Notes:
Aplasmomycin A was isolated from culture filtrate of Streptomyces griseus SS-20. Its structure was determined by X-ray crystallographic analysis of its Ag-salt. Aplasmomycin A inhibited the growth of Gram-positive bacteria including mycobacteria and it showed antimalarial activity in mice infected with Plasmodium berghei. Aplasmomycin A specifically inhibited the futalosine pathway of menaquinone biosynthesis.
References:
1) Studies on marine microorganisms. V. a new antibiotic, aplasmomycin, produced by a streptomycete isolated from shallow sea mud. Okami Y, et al. J Antibiot. 1976 29(10) 1019-1025.
2) Structure of aplasmomycin. Nakamura H, et al. J Antibiot. 1977 30(9) 714-719.
3) Aplasmomycin and boromycin are specific inhibitors of futalosine pathway. Shimizu Y, et al. J Antibiot. 2018 71(11) 968 -970.
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|---|---|---|---|---|---|---|---|---|
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Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei. | Current Link | ||||
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