Migrastatin
Product#: FNK-10708
$598.00
Availability:
Ships in 24 hours
Migrastatin
Cat. No. FNK-10708
Size 1 mg
Storage -20 oC
CAS 314245-65-3
Molecular Formula C27H39NO7
Molecular Weight 489.609
Source Streptomyces sp. MK929-43F1
Appearance White powder
Purity > 90% (HPLC)
Solubility Soluble in MeOH, DMSO, DMF. Insoluble in H2O.
Application Notes
- Migrastatin inhibits cell migration of human esophageal cancer (EC17) & mouse melanoma (B16) cells 1).
- It was found to inhibit anchorage-independent growth of human small cell lung carcinoma (Ms-1) cells 2).
Reference
- Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities. Nakae K, Yoshimoto Y, Sawa T, Homma Y, Hamada M, Takeuchi T, Imoto M. J. Antibiotics, 2000, 53, 1130-1136.
- Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells. Takemoto Y, Nakae K, Kawatani M, Takahashi Y, Naganawa H, Imoto M. J. Antibiotics, 2001, 54, 1104-1107.
- Absolute configuration of migrastatin, a novel 14-membered ring macrolide. Nakamura H, Takahashi Y, Naganawa H, Nakae K, Imoto M, Shiro M, Matsumura K, Watanabe H, Kitahara T. J. Antibiotics, 2002, 55, 442-444
Related Products
| Effect of Chemicals | Name | Product Code | Link |
|---|---|---|---|
| Aflatoxin Production Inhibitor | Dioctatin A (HCl) | FNK-14700 |  |
| Tumor Cell Migration Inhibitor | Migrastatin | FNK-10708 | Current Link |
| Anti-Tumor | Altemicidin | FNK-12151 | |
| Bisucaberin | FNK-14659 | |
|
| COMC | FNK-14701 | |
|
| COTC | FNK-14675 | |
|
| 6-epi-COTC | FNK-14698 | |
|
| Forphenicinol | FNK-09637 | |
|
| Inostamycin A (Na Salt) | FNK-14652 | |
|
| Lentztrehalose A | FNK-14678 | |
|
| Migrastatin | FNK-10708 | Current Link | |
| Oxanosine | FNK-00762 | |
|
| Immunomodifier | Forphenicinol | FNK-09637 | |
| Mannan Lectin | Benanomicin A | FNK-02966 | |
Natural macrocyclic compounds from microorganisms:
| Structural classification | Compound Name | Chemical Structure | Property / Biological activity | Link | ||||
|---|---|---|---|---|---|---|---|---|
| Bacterial proteins/Inhibition of DNA synthesis | Aplasmomycin (Sodium Salt) |  |
Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei. | |
||||
| Migrastatin |  |
Migrastatin inhibited metastasis of human esophageal cancer cells and anchorage-independent growth of human small cell lung carcinoma cells. | Current Link | |||||
| Macrolactams | Bisucaberin |  |
Bisucaberin is a siderophore with iron-affinity and induced concentration dependent macrophage-mediated tumor cell lysis. | |
||||
| Cyclic peptides | Bottromycin A2 |  |
Bottromycin A2 showed growth inhibitory activity against gram-positive bacteria, MRSA (Methicillin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci). | |
||||
| Iturin A-2 |  |
Iturin A-2 showed the control of damping-off of tomato (a seedling disease) and cytotoxicity to human breast cancer cell line BT-474. | |
|||||
| Plipastatin A1 |  |
Plipastatin A1 inhibited phospholipase A2 and induced ISR (induced-systemic-resistance). | |
|||||
| Phepropeptin A |  |
Phepropeptin A inhibited proteasomal chymotrypsin-like activity. | |
|||||
| Phepropeptin B |  |
Phepropeptin B inhibited proteasomal chymotrypsin-like activity. | |
|||||
| Phepropeptin C |  |
Phepropeptin C inhibited proteasomal chymotrypsin-like activity. | |
|||||
| Phepropeptin D |  |
Phepropeptin D inhibited proteasomal chymotrypsin-like activity. | |
|||||
| Cycloalkenes | Rubratoxin A |  |
Rubratoxin A inhibited protein phosphatase 2A (PP2A) in a competitive manner. | |
||||
Recently Viewed
pBIDAVL-GWR1 Vector
$693.56
J-Rack Yellow
$35.84
pH35CG Vector
$990.77
pBIDAVL-GWR2 Vector
$693.56
FAM ADIBO
$797.28
RotoBot Mini Rotating Mixer
$823.21
RotoBot Rotating Mixer
$1211.76
pH35GC Vector
$990.77
2D Everlast 247 Rocker
$167.50