Benanomicin A
Product#: FNK-02966
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Benanomicin A
Specifications
Code No.: FNK-02966
CAS#: 116249-65-1
Molecular Formula: C39H41NO19
Molecular Weight: 827.745
Source: Actinomadura sp. MH193-16F4
Appearance: Dark red powder
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO, DMF. Poorly soluble in MeOH, CHCl3. Insoluble in H2O.
Application Notes
CAS#: 116249-65-1
Molecular Formula: C39H41NO19
Molecular Weight: 827.745
Source: Actinomadura sp. MH193-16F4
Appearance: Dark red powder
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO, DMF. Poorly soluble in MeOH, CHCl3. Insoluble in H2O.
Benanomicin A is isolated from the culture filtrates of Actinomadura sp. MH193-16F4.1,2 It shows excellent activities against a wide range of fungi including Candida, Cryptococcus and Aspergillus.1,3 Benanomicin A demonstrated excellent therapeutic efficacy against in a Pneumocystis carinii-infected mouse model.4 Benanomicin A also inhibited infection of human T-cells with human immunodeficiency virus (HIV-1) at 30~100 μg/mL and inhibited syncytium formation induced by HIV-1 at 10~100 μg/mL.5 The antifungal and anti HIV-1 activities of benanomicins and their analogues have been studied.6 Benanomicin A has antimycotic activities via binding to mannan in the cell walls of fungi. 7 In recent years, the lectin-like functionality of Benanomicin A has been utilized to conduct research on preparing the mannan cell walls. 8,9
References
- New antifungal antibiotics, benanomicins A and B from an actinomycete. Takeuchi T, et al. J Antibiot. 1988 41(6) 807-811
- The structures of new antifungal antibiotics, benanomicins A and B. Gomi S, et al. J Antibiot. 1988 41(8) 1019-1028.
- The in-vitro activity of an antifungal antibiotic benanomicin A in comparison with amphotericin B. Watanabe M, et al. J Antimicrob Chemother. 1996 38(6) 1073-1077.
- Successful treatment of Pneumocystis carinii pneumonia in mice with benanomicin A (ME1451). Yasuoka A, et al. Antimicrob.
Agents. Chemother. 1995 39(3) 720-724. - New antifungal antibiotics, benanomicins A and B inhibit infection of T-cell with human immunodeficiency virus (HIV) and syncytium formation by HIV. Hoshino H, et al. J Antibiot. 1989 42(2) 344-346.
- Antifungal and antiviral activities of benanomicins and their analogues. Kondo S, et al. J Antibiot. 1991 44(11) 1228-1236.
- Binding of benanomicin A to fungal cells in reference to its fungicidal action. Watanabe M, et al. J Antibiot. 1996 49(4) 366-373.
- Presence of O-glycosidically linked oligosaccharides in the cell wall mannan of Candida krusei purified with Benanomicin A.Kuraoka T, et al. FEBS Open Bio. 2019 9 129～136.
- Distribution of oligomannosyl side chains in the cell wall mannan of pichia pastoris purified by benanomicin A. Kuraoka T, et al.
Int J Curr Microbiol App Sci. 2019.8(1) 2926-2935.
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| Mannan Lectin | Benanomicin A | FNK-02966 | Current Link |
| Infection Related | Name | Product Code | Link |
|---|---|---|---|
| Anti-HIV-Ⅰ | Benanomicin A | FNK-02966 | Current Link |
| Benanomicin B | FNK-02968 | |
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| Anti-MRSA, Anti-VRE | Bottromycin A2 | FNK-00592 | |
| Anti-Gram Positive / Negative Bacteria |
Althiomycin | FNK-14660 | |
| Cyclamidomycin | FNK-01541 | |
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| Negamycin (HCl) | FNK-14662 | |
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| Anti-Gram Positive Bacteria | Bottromycin A2 | FNK-00592 | |
| Anti-Respiratory Infectious Bacteria | Forphenicinol | FNK-09637 | |
| Acid-Fast Bacillus Growth Suppression | Minosaminomycin | FNK-02872 | |
| Antifungal | Benanomicin A | FNK-02966 | Current Link |
| Benanomicin B | FNK-02968 | |
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| Bacterial Protein Synthesis Inhibitor | Althiomycin | FNK-14660 | |
| Minosaminomycin | FNK-02872 | |
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| Negamycin (HCl) | FNK-14662 | |
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| Pneumocystis pneumonia suppression |
Benanomicin A | FNK-02966 | Current Link |
