Forphenicinol (Immunomodifier)

Cat No.: FNK-09637

Specifications

Code No.: 09637
CAS#: 71522-58-2
Molecular Formula: C9H11NO4
Molecular Weight: 197.190
Source: Synthetic derivative of forphenicine
Appearance: White powder
Purity: >90% (HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in MeOH, DMSO, H2O Insoluble in Hexane

Description

Forphenicinol is a synthesized derivative of forphenicine, the inhibitor of alkaline phosphatase produced by Streptomyces. 1,2) Forphenicinol augments delayed-type hypersensitivity (DTH) response induced by both sheep red blood cells (SRBC) or oxazolone by oral administration of 1-100 μg/mouse. 3) The treatment with forphenicinol restores DTH in mice immuno-suppressed by cyclophosphamide to normal response at 100 μg/mouse. 3) Forphenicinol neither augments antibody-formation nor stimulates proliferation of lymphocytes in the presence or absence of lectins. 3) Phagocytosis by peritoneal macrophages is enhanced by forphenicinol in vivo and in vitro. 3)

Forphenicinol is effective in increasing the production of the colonyforming unit in culture (CFU-C) in the presence of colony stimulating factor and partially prevents the reduction of leucocyte counts caused by mitomycin C. 3) Ehrlich carcinoma is suppressed by treatment with 0.08-0.31 mg/kg/day of forphenicinol given for 10 days starting 5 days after tumor inoculation but it does not show antitumor effect in larger doses. 4) IMC carcinoma is also suppressed by treatment with 0.5-5 mg/kg/day given for 5 days starting 8 days after the inoculation. 4) In case of fast-growing tumors such as L1210, forphenicinol does not show any effect on prolongation of the survival period, but it markedly enhances the antitumor effect of 6-mercaptopurine, aclacinomycin or cyclophosphamide. 4) Forphenlcinol shows a protective effect on mouse model of Pseudomonas aeruginosa infection. 4)


References

1) Forphenicine, an inhibitor of alkaline phosphatase produced by actinomycetes. Aoyagi T, et al. J Antibiot. 1978 31(3) 244-246.
2) Synthesis of forphenicinol and forphenicine. Morishima H, et al. J Antibiot. 1982 35(11) 1500-1506.
3) Studies on effects of forphenicinol on immune responses. Ishizuka M, et al. J Antibiot. 1982 35(8) 1042- 1048.
4) Antitumor effect of forpheniciol, a low molecular weight immunomodifier, on murine transplantable tumors and microbial infections. Ishizuka M, et al. J Antibiot. 1982 35(8) 1049-1054.


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