Inostamycin A
Product#: FNK-14652
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Inostamycin A
Specifications
Code No.: FNK-14652 (InostamycinA sodium salt)
CAS#: 129905-10-8
Molecular Formula: C38H68O11
Molecular Weight: 700.951
Source: Streptomyces sp. MH816-AF15
Appearance: white powder
Purity: > 90%(Quantitative NMR)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO, DMF. Slightly soluble in MeOH, CHCl3 Insoluble in H2O.
CAS#: 129905-10-8
Molecular Formula: C38H68O11
Molecular Weight: 700.951
Source: Streptomyces sp. MH816-AF15
Appearance: white powder
Purity: > 90%(Quantitative NMR)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO, DMF. Slightly soluble in MeOH, CHCl3 Insoluble in H2O.
Application Notes
Inhibitor of phosphatidylinositol turnover. It inhibits EGF-induced inositol incorporation into inositol lipids with an IC50of about 0.5 µg/ml in the A431 cell assay system1. Inostamycin A has antimicrobial activities against Gram-positive bacteria and cytocidal activity against srk-NIH-3T3 cell with IC50 value of 0.07 µg/ml 2. Inostamycin A potenciates colchitine cytotoxicity toward KB-C4 cells at 3 µg/ml 3. Inostamycin A causes Ms-1 cell to accumulate in the G1 phase at 0.1 µg/ml and induces morphological apoptosis at high concentration (0.3 µg/ml) 4.
References
- Isolation and structure determination of inostamycin, a novel inhibitor of phosphatidylinositol turnover. Imoto, M., Umezawa, K., Takahashi, Y., Naganawa, H., Iitaka, Y., Nakamura, H., Koizumi, Y., Sasaki, Y., Hamada, M., Sawa, T., Umezawa, H. & Takeuchi, T. J. Nat. Prod.53, 825-829(1990).
- InostamycinB and C, new polyether antibiotics. Odai, H., Shindo, K., Odagawa, A., Mochizuki, J., Hamada, M. & Takeuchi, T. J. Antibiot.47, 939-941 (1994).
- Circumvention of multidrug resistant in human carcinoma KB cells by polyether antibiotics. Kawada, M., Sumi, S., Umezawa, K., Inoue, S., Sawa, T. & Seto, H. J. Antibiot.45, 556-562 (1992).
- Inhibition of cyclin D1 expression and induction of apoptosis by inostamycinin small cell lung carcinoma cells. Imoto, M., Tanabe, K., Simizu, S., Tashiro, E., Takada, M. & Umezawa, K. Jpn. J. Cancer Res. 89, 315-322 (1998).
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