Foroxymithine, ACE Inhibitor, Hypotensiven, Siderophore
Product#: FNK-16968
$598.00
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Foroxymithine, ACE Inhibitor, Hypotensiven, Siderophore
Specifications
Code No : FNK-16968
CAS# : 100157-28-6
Size: 5 mg
Molecular Formula : C22H37N7O11
Molecular Weight : 575.576
Source : Streptomyces nitrosporeus
Appearance : Powder
Purity : > 95% (HPLC)
Long Term Storage : at - 20 °C
Solubility : Soluble in H2O, DMSO
Fairly soluble in MeOH
Application Notes
Foroxymithine was isolated from culture filtrate of Streptomyces nitrosporeus MG329-CF56 as an inhibitor of angiotensin-converting enzyme (ACE).1) It showed an IC50 value of 7 μg/ml against ACE (bovine lung). 1) The oral administration of foroxymithine dihydrate significantly reduced systolic blood pressure in spontaneously hypertensive rats. 1) A tyrosine kinase inhibitor, erbstatin, is decomposed in serum by ferric ion. Foroxymithine is a siderophore, a potent chelator of ferric ion, and prevented its decomposition by serum. 2)
References
1) Foroxymithine, a new inhibitor of angiotensin-converting enzyme, produced by Actinomycetes. Umezawa H, et al. J
Antibiot. 1985 38(12) 1813-1815.
2) Antitumor activity of erbstatin, a tyrosine protein kinase inhibitor. Imoto M., et al. Jpn. J. Cancer Res. 1987 78 329-332.
Description
Foroxymithine is a compound with the chemical formula C22H37N7O11 that functions as an inhibitor of angiotensin-converting enzyme (ACE)[9][10]. It was discovered as a product of microbial fermentation by actinomycetes, a type of bacteria[10].
As an ACE inhibitor, foroxymithine likely has potential applications in treating hypertension and other cardiovascular conditions, though more research would be needed to confirm its clinical efficacy and safety. The compound's ability to inhibit ACE suggests it may help lower blood pressure by reducing the production of angiotensin II, a potent vasoconstrictor[10].
Foroxymithine is primarily used as a biochemical assay reagent in research settings[13]. It is available commercially from scientific suppliers, with prices around $370 for research-grade quantities[11].
The chemical structure and properties of foroxymithine have been studied, and methods for its laboratory synthesis have been developed[12]. This allows researchers to produce the compound without relying solely on microbial fermentation.
It's important to note that while foroxymithine shows promise as an ACE inhibitor in laboratory studies, it is not currently approved as a medication for human use. Further research would be required to evaluate its potential therapeutic applications and safety profile.
Citations:
[1] https://www.amazon.com/Oxymatrine-84-tablets-White-Tiger/dp/B002F360RM?psc=1&smid=A1SDL9ZRQZE5IK
[2] https://hsioutlet.com/bci-handheld-pulse-oximeter-adult-d/
[3] https://www.chemdirect.com/p/ChemD-196-B2703-173027-1x20-Milligram-19773-24-1/peimisine-98-1x20-milligram-354589?utm=gmcusercampaign
[4] https://www.walmart.com/ip/Veridian-Healthcare-Pediatric-Pulse-Oximeter/2871159732?selectedSellerId=0&wmlspartner=wlpa
[5] https://www.professionalsupplementcenter.com/fucothin-natural-fat-burner-by-garden-of-life?quantity=1&size=2619
[6] https://www.ebay.com/itm/134898108525?chn=ps&mkcid=28&mkevt=1
[7] https://www.oxygenconcentratorsupplies.com/precision-medical-pm4150-easypulse
[8] https://hacenoroxygen.com/products/low-noise-mini-vehicle-travel-use-1l-continuous-flow-oxygen-concentrator-kj-8000?currency=USD&variant=40537957105746
[9] https://pubchem.ncbi.nlm.nih.gov/compound/Foroxymithine
[10] https://pubmed.ncbi.nlm.nih.gov/3005216/
[11] https://www.caymanchem.com/product/40228
[12] https://pubs.acs.org/doi/10.1021/jo00002a005
[13] https://www.medchemexpress.com/foroxymithine.html
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| Infectious Disease Prevention | Compound Name | Product Code | Link | ||||
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