Bactobolamine (Immunosuppressant)
Product#: FNK-15160
$598.00
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Bactobolamine (Immunosuppressant)
Cat. No.: FNK-15160Size: 1mg
CAS#: 78013-07-7
Molecular Formula: C11H15Cl2NO5
Molecular Weight: 312.143
Source: Synthetic derivative of bactobolin A
Supplied as: Powder
Purity: >98% (HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO, H2O
Description
Bactobolamine is a synthetic derivative of a Pseudomonas metabolite bactobolin A. Bactobolamine suppresses proliferative lymphocytic responses such as concanavalin A induced lymphoblast formation, and it induces significant prolongation of allograft survival. Low-dose bactobolamine when combined with low-dose tacrorimus prolongs markedly the survival of rat liver allografts. Low-dose bactobolamine when combined with low-dose cyclosporine inhibits the human mixed-lymphocyte reaction.
References
1) Bactobolins, antitumor antibiotics from Pseudomonas. II, synthesis and biological activities of related compounds. Munakata T, et. al. YakugakuZasshi1981 101(2) 138-147.
2) Effectiveness of bactoboamineas a new immunosuppressive agent. TomikawaS,et al. Transplant Proc. 1997 29(1-2) 12761278.
3) Immunosuppressive effect of bactobolamineon in vitro lymphocyte alloactivation: synergism with cyclosporine. Imai T,et al. Transplant Proc. 200032(7)2060-2062.
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