Conagenin, Immunomodulator
Product#: FNK-16969
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Conagenin, Immunomodulator
Specifications
Code No : FNK-16969
CAS# : 134381-30-9
Size: 1 mg
Molecular Formula : C10H19NO6
Molecular Weight : 249.263
Source : Streptomyces roseosporus
Appearance : Powder
Purity : > 98% (HPLC)
Long Term Storage : at – 20 °C
Solubility : Soluble in H2O, MeOH, DMSO
Insoluble in Hexane, EtOAc
Application Notes
Conagenin was isolated from culture filtrate of Streptomyces roseosporus MI696-AF3 as an immunomodulator that enhanced incorporation of thymidine into T cells activated by concanavalin A. 1) Conagenin enhanced production of cytokines such as IL-2, 3 and 6. 2,3) Cytotoxic T lymphocytes and natural killer activities in spleens of conagenin treated mice were maintained at higher levels than those of non-treated mice. 3) Phagocytosis of alveolar macrophages against opsonized-sheep red blood cells was enhanced following in vitro incubation with conagenin. 4) Note: The stock solution should be stored at 4 °C or lower and should be used within a couple of days.
Conagenin is a natural product isolated from the culture broths of Streptomyces bacteria, specifically Streptomyces roseosporus and Streptomyces filamentosus. It is classified as a N-acyl-L-amino acid and has the molecular formula C10H19NO6
This compound is considered a unique and biologically important secondary metabolite[2]. While the specific details of its biological activity are not provided in the search results, it is described as an immunomodulato], suggesting that it may have effects on the immune system.
Conagenin has attracted scientific interest, as evidenced by research into its synthesis. In 2005, a study reported the successful synthesis of (+)-Conagenin, indicating efforts to produce this compound artificially for further study or potential applications
References
1) Conagenin, a low molecular weight immunomodulator produced by Streptomyces roseosporus. Yamashita T, et al. J Antibiot. 1991 44(5) 554-559.
2) T cell activation by conagenin in mice. Kawatsu M, et al. J Antibiot. 1993 46(11) 1687-1691.
3) Effect of conagenin in tumor bearing mice antitumor activity, generation of effector cells and cytokine production. Kawatsu M, et al. J Antibiot. 1993 46(11) 1692-1698.
4) Conagenin derived from Streptomyces roseosporus enhances macrophage functions. Hamada M, et al. J Antibiot. 1999 52(6) 548-551.
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