Bactobolin A (hydrochloride), Antitumor, Antibacterial 

Cat. No.: FNK-08465

Size: 1mg
Parent CAS#: 72615-20-4 (salt free form)
Molecular Formula: C₁₄H₂₀Cl₂N₂O₆ HCl
Molecular Weight: 419.680
Source: Pseudomonas sp.
Supplied as: Powder, hydrochloride salt
Purity: >95% (HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO, H2O

Description

Bactobolin A was isolated from the fermentation broth of Pseudomonas sp. BMG13-A7. Bactobolin A has broad-spectrum antibacterial activity and prolongs the survival period of mice bearing leukemia L1210. The acute toxicity of bactobolin A is estimated at 6.25-12.5 mg/kg in CDF1 mice by a single intraperitoneal injection. It is reported that bactobolin A binds to a site on the 70S ribosome, which was different from the other antibiotics previously known.

References
1) A new antitumor antibiotic, bactobolin produced by Pseudomonas. Kondo S,et al. J Antibiot. 1979 32(10) 1069-1071.
2) Antitumor effect of bactobolin and its influence on mouse immune system and hematopoietic cells. Ishizuka M,et al. JAntibiot. 1980 33(9) 1054-1062.
3) Bactobolin A binds to a site on the 70S ribosome distinct from previously seen antibiotics. Amunts, A. et al. J Mol Biol. 2015,  427(4) 753-755.

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