Actinobolin (sulfate) (Protein and DNA Synthesis Inhibitor)
Product#: FNK-15172
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Actinobolin (sulfate) <Protein and DNA Synthesis Inhibitor>
Cat No.: FNK-15172Size: 1mg
Specifications
Code No. : 15172
CAS# : 18802-17-0
Molecular Formula : C13H20N2O6 1/2 H2SO4
Molecular Weight : 349.347
Source : Streptomyces sp.
Supplied as : Powder
Purity : >98 % (HPLC)
Long Term Storage : at -20 °C
Solubility : Soluble in MeOH, DMSO and H2O
Application Notes
Actinobolin was isolated from fermentation broth of Streptomyces griseoviridis var. atrofaciens. Actinobolin had inhibitory activity against microbial cultures, tentatively identified as strains of Bacteroides melaninogenicus, Fusobacterium fusiforme, Leptotrichia buccalis and Veillonella parvula, obtained from patients with periodontal disease. Actinobolin inhibited protein synthesis in Escherichia coli. In mouse Adenocarcinoma 755 cells, both in vivo and in cell culture, actinobolin inhibited the synthesis of protein and DNA.
References
1) Actinobolin and its fermentative production. Haskell T H, et al. US Patent. 1962 3043830.
2) The structure and chemistry of actinobolin. Antosz F J, et al. J Am Chem Soc. 1970 92(16) 4933-4942.
3) In vitro evaluation of actinobolin as an antibiotic for the treatment of periodontal disease. Armstrong P J Jr, et al. Appl
Microbiol. 1972 23(1) 88-90.
4) The effect of actinobolin of nucleic acid and protein synthesis in Escherichia coli. Hunt D E, et al. Can J Microbiol. 1966
12(3) 515-520.
5) Inhibition of protein synthesis in mammalian cells by actinobolin. Smithers D, et al. Mol Pharmacol. 1969 5(5) 433-445.
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