Oudenone(potassium salt), Tyrosine hydroxylase inhibitor, Hypotensive
Product#: FNK-16640
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Oudenone(potassium salt), Tyrosine hydroxylase inhibitor, Hypotensive
Specifications
Code No.: FNK-16640
CAS#: 34200-97-0 (assigned to the planar structure of oudenone potassium salt)
Size: 1 mg
Molecular Formula: C12H17O4K
Molecular Weight: 264.362
Source: Oudemansiella radicata
Supplied as: Powder Purity : >98 % (HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in H2O and DMSO
Description
Oudenone(potassium salt) is a derivative of the fungal metabolite oudenone and functions as a tyrosine hydroxylase inhibitor[2][4]. It is also known as CAY10799 (potassium salt) and has hypotensive properties[1][3].
The compound has a molecular weight of 264.4 D and is available commercially with a purity of ≥98%[2][5]. Its CAS number is 34200-97-0[2][5].
The substance is primarily used as a biochemical reagent in research settings, and it's important to note that it should be handled with appropriate precautions due to its biological activity[4][5].
Citations:
[1] https://www.diagnocine.com/Product/Oudenonepotassium-salt-Tyrosine-hydroxylase-inhibitor-Hypotensive/94008
[2] https://www.caymanchem.com/product/40227/cay10799-%28potassium-salt%29
[3] https://nordicbiosite.com/product/181-16640/Oudenonepotassium-salt-Tyrosine-hydroxylase-inhibitor-Hypotensive
[4] https://www.medkoo.com/products/56513
[5] https://www.biomol.com/products/chemicals/biochemicals/cay10799-potassium-salt-cay40227-1
Application Notes
Oudenone was isolated from fermentation broth of Oudemansiella radicata 10F as an inhibitor of tyrosine hydroxylase (IC50: 1.1×10-4 M).1-2)
It also inhibited phenylalanine hydroxylase (IC50: 2.3×10-3M) and showed strong hypotensive effect.1,3)
Relevance in Human Disease
- Hypotensive Effects: Oudenone has been shown to have blood pressure-lowering properties. Studies have demonstrated that it can significantly reduce blood pressure in hypertensive models, such as genetically hypertensive rats. This makes it a compound of interest for research into treatments for hypertension.
- Enzyme Inhibition: As a tyrosine hydroxylase inhibitor, oudenone affects the synthesis of catecholamines, which are neurotransmitters that play a role in the regulation of blood pressure. This mechanism contributes to its hypotensive effects
Cell Signaling Pathway
- As a tyrosine hydroxylase inhibitor, oudenone(potassium salt) likely affects catecholamine synthesis, which could explain its hypotensive (blood pressure-lowering) effects[1][3]. This makes it a potentially interesting compound for research in areas related to blood pressure regulation and catecholamine metabolism.
References
1) A new microbial product, oudenone, inhibiting tyrosine hydroxylase. Umezawa H, et al. J Antibiot. 1970 23(10) 514-518.
2) Oudenone, a novel tyrosine hydroxylase inhibitor from microbial origin. Ohno M, et al. J Am Chem Soc. 1971 93(5) 1285-
1286.
Related Products:
| Enzyme Inhibitors | Compound Name | Product Code | Link | ||||
|---|---|---|---|---|---|---|---|
| Serine carboxypeptidase inhibitor | Belactin A | FNK-17736 |  |
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| Tyrosine hydroxylase inhibitor | Oudenone (Potassium Salt) | FNK-16640 | Current Link | ||||
| Proteasome inhibitor | Phepropeptin A | FNK-16964 | |
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| Phepropeptin B | FNK-16965 | |
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| Phepropeptin C | FNK-16966 | |
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| Phepropeptin D | FNK-16967 | |
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| Angiotensin-converting enzyme (ACE) inhibitor | Foroxymithine | FNK-16968 | |
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| Biological Activity on Cells and Organisms | Compound Name | Product Code | Link | ||||
| Inhibition of NO production in macrophage | SF2425 (Sulfate) | FNK-17577 | |
||||
| Antitumor effect/Cytotoxicity/Anti-angiogenesis | Bactobolin A (Hydrochloride) | FNK-08465 | |
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| Clazamycin A (Hydrochloride) | FNK-16715 | |
|||||
| Lavendamycin | FNK-16734 | |
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| MC-1 | FNK-16479 | |
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| Immunomodulation/Immunosuppressant effect | Bactobolamine | FNK-15160 | |
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| Conagenin | FNK-16969 | |
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| Siderophore | Foroxymithine | FNK-16968 | |
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| Antihypertensive effect | Oudenone (Potassium Salt) | FNK-16640 | Current Link | ||||
| Infectious Disease Prevention | Compound Name | Product Code | Link | ||||
| Antibacterial activity/Antifungal activity | SF2425 (Sulfate) | FNK-17577 | |
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| Lavendamycin | FNK-16734 | |
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| Antimalarial | Aplasmomycin (Sodium Salt) | FNK-17683 | |
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| Bacterial proteins/Inhibition of DNA synthesis | Actinobolin (Sulfate) | FNK-15172 | |
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| Clazamycin A (Hydrochloride) | FNK-16715 | |
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