1. Amyloidogenic ApoA-I induces cell death is through attenuating anti-stress activity of angiogenin. PMID: 24603325
2. Data show that the transcription of angiogenin (ANG) and ribonuclease 4 (RNASE4) promoter is influenced by RNA polymerase III (Pol III) elements and could be differentially regulated by an intragenic CCCTC binding factor (CTCF)-dependent chromatin loop. PMID: 24659782
3. High angiogenin expression is associated with bladder cancer. PMID: 24696417
4. Angiogenin was up-regulated in proliferative hemangiomas. Angiogenin serum levels correlate with the hemangioma stage. Angiogenin levels discriminate between proliferative hemangiomas and the control group and patients with venous malformations. PMID: 25068345
5. The observed pattern of angiogenin expression is compatible with a role in blood vessel formation and in cross-talk between trophoblasts and endothelial cells. PMID: 25093183
6. a novel mechanism of ANG in regulating PI3K/AKT/mTOR signaling pathway via RI, is reported. PMID: 25193113
7. a biological explanation for the loss-of-function of D22G-Angiogenin leading to ALS, and suggest that the L35P-Angiogenin mutation would probably cause ALS symptoms in individuals harboring this mutation PMID: 25372031
8. ANG rs11701 variant is a genetic risk factor for Parkinson's disease in Taiwan population.Mutations in ANG are not a common cause for idiopathic Parkinson's disease. PMID: 25386690
9. Studied the mechanism of ligand binding in human angiogenin using the NMR chemical shift projection analysis. PMID: 25450558
10. Up-regulated ANG expression and increased nuclear translocation were observed in cervical cancers as compared to normal cervical tissues; upregulation of ANG was positively correlated with primary tumor invasion PMID: 25552400
11. ANG could play a pivotal role in the development of bladder cancer through regulating AKT/mTOR signaling pathway. PMID: 25564356
12. In conclusion, angiogenin secretion by HCCs favors tumor development by inducing HSC activation and ECM remodeling. PMID: 25604905
13. the present study established a link between Ang and FHL3 proteins and identifies a new pathway for regulating astrocytoma progression. PMID: 25659096
14. ANG K17I variant is rare in Caucasian patients and controls and increases the risk for amyotrophic lateral sclerosis PMID: 26255299
15. Suggest a novel regulatory pathway whereby breast tumor-derived angiogenin directly activates angiogenesis through inhibition of miR-542-3p. PMID: 26272182
16. There is Lack of association between the Angiogenin (ANG) rs11701 polymorphism and amyotrophic lateral sclerosis risk. PMID: 26753798
17. Results continue to establish ANG as an oncoprotein and further reveal that ANG contributes to oncogenesis by the activation of MMP2 through modulation of DNMT3b functions. PMID: 27317771
18. ANG plays a non-cell-autonomous role in regulation of hematopoiesis by simultaneously preserving hematopoietic stem/progenitor cells stemness and promoting myeloid-restricted progenitor cell proliferation. PMID: 27518564
19. RNase 5 suppressed p27 and up-regulated cyclin D1, D3, and E by activating PI3-kinase/Akt in CECs to initiate cell cycle progression PMID: 27526633
20. Ang down-regulate the expression of Col-I, alpha-SMA and TGF-beta1/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition. PMID: 27543459
21. we found that ANG plays an important role in EMT in squamous cell lung carcinoma and may be a valuable therapeutic target for squamous cell lung carcinoma PMID: 27667357
22. Ang,Tie1 and Tie2 play roles in vascular development and pathogenesis of vascular diseases.[review] PMID: 27941161
23. Results indicate that angiogenin (ANG) plays a critical role in regulating angiogenesis and follicle survival in xenografted human ovarian tissues. PMID: 28274269
24. Delivery of the therapeutic human genes VEGF and ANG using an adenoviral vector improved functional recovery after traumatic spinal cord injury in a rat model. Immunofluorescent analysis of the post-treatment spinal cord suggested that the positive effect of Ad5-VEGF+Ad5-ANG transduction on recovery of locomotor function may be due to the action of glial cells on motor neurons. PMID: 28452633
25. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas PMID: 28561015
26. When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy PMID: 28596290
27. The results revealed that PCNA is predominantly localized in the cytoplasm, while hAng is distributed both in the nucleus and in the cytoplasm. hAng and PCNA colocalize in the cytoplasm, suggesting that they may interact in this compartment. PMID: 28777577
28. Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells. PMID: 29100074
29. (31) RRR(33) and (50) KRSIK(54) motifs of angiogenin might play a critical role in the regulation of p53-mediated apoptosis and angiogenesis in cancer cells. PMID: 29105754
30. Angiogenin contributes to angiogenesis induced by Brain-derived neurotrophic factor (BDNF). PMID: 29573867
31. Data show that phospholipase D2 (PLD2)-produced phosphatidic acid (PA) promoted cell invasion through the the expression of angiogenin (ANG) in clear cell renal cell carcinoma (ccRCC) cells. PMID: 29660846

HGNC: 483

OMIM: 105850

KEGG: hsa:283

STRING: 9606.ENSP00000336762

UniGene: Hs.283749