1. AMBP has radical scavenging activity. PMID: 17766242
2. urinary trypsin inhibitor is insufficiently produced for neutrophil elastase release after cardiac arrest PMID: 17998887
3. in multiple myeloma patients without renal failure, elevated Alpha-1-microglobulin excretion might be an early marker of renal tubular involvement PMID: 18046670
4. In the present study, structural motifs regulating bikunin's anti-inflammatory function are delineated. Binding of bikunin to neutrophils is critically important for its anti-inflammatory capacity. PMID: 18226914
5. The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2. PMID: 18448433
6. Overexpression of bikunin reduced the gene expression of matriptase, which attenuated in vitro cell invasion in prostate cancer. PMID: 18649735
7. Overexpression of Urinary trypsin inhibitor is associated with recurrence in hepatocellular carcinoma. PMID: 19636634
8. increased protein levels in preeclamptic women PMID: 19879940
9. significant relationship was established between the low level and absence of bikunin, and pro-u-PA in urine samples from patients with bladder tumors; identified bikunin loss in urine as a potential bladder carcinoma marker PMID: 19914646
10. These findings suggest that there was no significant association in genotype distribution of Init-2 polymorphism of the AMBP gene between patients with kidney stones and healthy controls. PMID: 20602574
11. The promoter of AMBP gene had polymorphisms at positions -218 and -189 nt giving three different genotypes with no association between these observed genotypes and kidney stone-forming phenotypes. PMID: 20602574
12. the cell-protective effects of alpha(1)-microglobulin during alpha-particle irradiation PMID: 20954860
13. urinary marker for the differential diagnosis of Balkan endemic nephropathy PMID: 21332340
14. The results suggest that A1M may have a physiological role in protection of skin cells and matrix against oxidative damage following bleeding. PMID: 22096585
15. Report prognostic value of urinary alpha 1-macroglobulin in idiopathic membranous nephropathy. PMID: 22595828
16. crystal of alpha1-microglobulin belonged to space group P4(3), with unit-cell parameters a = b = 36.45, c = 112.68 A PMID: 22684072
17. High urine alpha-1-microglobulin is associated with ischemic acute tubular necrosis than other causes of acute kidney injury. PMID: 23324582
18. High urine alpha-1-microglobulin is associated with interstitial fibrosis and tubular atrophy plus inflammation. PMID: 23414180
19. The antioxidative protection of cells and collagen by A1M is totally dependent on its C34 amino acid residue. PMID: 23642167
20. Sulfation of the bikunin chondroitin sulfate chain determines heavy chain.hyaluronan complex formation PMID: 23801333
21. our findings suggest that urine bikunin level, as well as proteinuria, could represent a useful parameter for monitoring renal function in those patients that do not present any symptoms of renal insufficiency. PMID: 23841057
22. In pre-term pregnant women with intact membranes, placental alpha-microglobulin-1 in cervicovaginal fluid test rates are more positive in cases of uterine contraction. PMID: 23919851
23. Determined is the first structure of human alpha-1-microglobulin with heavy electron density of the chromophore. PMID: 24012674
24. The high level of serum AMBP could predict the poor response of the AGC patients. PMID: 24135868
25. Label-free quantitative comparison of DN urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN. PMID: 24211404
26. placental alpha microglobulin-1 is a sensitive and specific test to assess rupture of membranes in patients with an equivocal diagnosis based on simple tests PMID: 24698819
27. Decreased bikunin mRNA level in renal cells might be associated with poor prognosis of renal carcinoma. PMID: 24980765
28. Proximal tubular dysfunction, indicated by urine alpha1-microglobulin, was independently associated with kidney function decline in HIV-infected and uninfected women and mortality risk among HIV-infected women. PMID: 25370597
29. results indicate a reduced UTI level in CSF of MS and NMO patients. The levels were associated with the severity of the two demyelinating diseases during relapse PMID: 25555815
30. Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan. PMID: 25561734
31. Data indicate that two heme groups can be bound simultaneously at separate sites in the antioxidant alpha1-microglobulin. PMID: 26497278
32. Prophylactic UTI maintains the endothelial barrier function, increases VE-cadherin expression, and inhibits the phosphorylation of VE-cadherin at Tyr658 under inflammatory conditions PMID: 26681130
33. Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. PMID: 26728454
34. There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia. PMID: 27155336

HGNC: 453

OMIM: 176870

KEGG: hsa:259

STRING: 9606.ENSP00000265132

UniGene: Hs.436911