1. Cell migration and production of inflammatory cytokines by the brain are enhanced by MSP stimulation in primary microglia. PMID: 18480548
2. The five gene transcripts (aldolase B, elafin, MST-1, simNIPhom and SLC6A14) were changed in patients with ulcerative colitis, and were related to the disease activity. PMID: 18700007
3. Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis. PMID: 19079170
4. Results suggest that hepatocyte growth factor activator is a major serum activator of pro-macrophage-stimulating protein. PMID: 19456860
5. The effect of BSN-MST1 locus on Crohn's disease predisposition was replicated, but no influence on ulcerative colitis or multiple sclerosis predisposition could be detected PMID: 19657358
6. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20014019
7. results suggest that MSP induces uPAR expression via MAPK, AP-1 and NF-kappaB signaling pathways PMID: 21081472
8. the oncogenic effect of BRAF(V600E) is associated with the inhibition of MST1 tumor suppressor pathways, and that the activity of RASSF1A-MST1-FoxO3 pathways determines the phenotypes of BRAF(V600E) tumors. PMID: 21249150
9. MSP-induced RSK2 activation is a critical determinant linking RON signaling to cellular EMT program. PMID: 21619683
10. considerable number of Merkel cell carcinoma cases expressed both RON and MSP, while Merkel cells do not express these molecules PMID: 21723047
11. These findings suggest that the MSP/RON signaling pathway may be regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders. PMID: 21875933
12. Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4). PMID: 21931648
13. the missense SNP impairs MSP function by reducing its affinity to RON and perhaps through a secondary effect on in vivo concentration arising from reduced thermodynamic stability, resulting in down-regulation of the MSP/RON signaling pathway. PMID: 22087277
14. HAT cleaves proMSP at the physiological activation site PMID: 22245154
15. The present results refine the known genetic architecture in primary sclerosing cholangitis by confirming MST1 locus association. PMID: 22554193
16. MSP may be one of the major determinants that affects the properties of tumor stroma and that produces a permissive microenvironment to promote cancer metastasis PMID: 23011677
17. Results suggest that the [AA] genotype of the common MST1 variant rs3197999 enhances genetic risk of sporadic extrahepatic cholangiocarcinoma irrespective of primary sclerosing cholangitis status. PMID: 23422030
18. Mst1 has an important role in inhibiting the growth of NSCLC in vitro and in vivo; its antiproliferative effect is associated with induction of apoptosis. PMID: 23928732
19. functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele PMID: 24409221
20. These results support the hypothesis that the alpha-chain of MSPalphabeta mediates RON dimerization. PMID: 25193665
21. MSP appears to promote the migration of fibroblasts, enhances collagen synthesis and remodeling, and effectively improves wound healing. PMID: 25315688
22. Identify MST1/MSP as a mitogen for tracheal basal cells. PMID: 25551685
23. Elevated serum levels of MST1 were found in subjects with excessive alcohol use. PMID: 25704570
24. These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis. PMID: 27609031

HGNC: 7380

OMIM: 142408

KEGG: hsa:4485

STRING: 9606.ENSP00000414287

UniGene: Hs.349110