1. key role in the process of heterotopic ossification PMID: 26919547
2. Seminal vesicles were evaluated by morphological and immunohistochemical parameters; androgenic receptor (AR), Insulin-like growth factor 1 (IGFR-1) and metalloproteinase 9 (MMP-9). Intense AR reactivity was seen in both stroma and epithelial regions in the TRAMP 22 group. Intense IGFR-1 and MMP-9 stromal immunolabeling was identified in both TRAMP groups PMID: 27036326
3. The results suggested that the relieving effect of KGLY against LPS-induced ALI might be partially due to suppression of oxidative stress and inflammatory response, inhibition of TLR4-mediated NF-kappaB activation, and down-regulation of MMP9 expression, indicating it may be a potential therapeutic agent for ALI. PMID: 27036629
4. NPY deficient mice had significantly impaired Hematopoietic stem/progenitor cell (HSPC) mobilization due to increased expression of HSPC maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9) activity in bone marrow. PMID: 27090492
5. Grooved surfaces showed time-dependent increase in soluble mediators involved in cell fusion, CCL2 and MMP-9 PMID: 27102570
6. MMP-9 inhibition results from a joint contribution between the components of the extract from Chilean Propolis and Pinocembrin PMID: 27119082
7. the ZnT3 null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 activity and BDNF levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD. PMID: 27352957
8. via binding to hypoxia-responsive elements in MMP9 gene, HIF1alpha stimulated MMP9 expression, and therefore appeared as a prominent intermediary in HB-EGF-induced blood-brain barrier damage PMID: 27431094
9. Our data suggest that MMP-9 deficiency does not result in major abnormalities in the development of any conventionally selected or agonist selected subsets and does not interfere with thymocyte apoptosis and clearance, and that MMP-9 expression is not induced in immature T cells at any stage of their thymic development. PMID: 27432536
10. In diabetes, transcription of retinal MMP-9 is maintained, in part, by an active DNA methylation-hydroxymethylation process, and regulation of this machinery should help maintain mitochondrial homeostasis and inhibit the development/progression of diabetic retinopathy. PMID: 27454437
11. Optical imaging demonstrated increased MMP activity in TB lesions and MMP-9 was significantly expressed in cavitary lesions. PMID: 27482816
12. Results show that ablation of systemic MMP-9 initiated fatal communication between maintenance of physiological functions of MMP-9 in the bone marrow and invasive growth of pancreatic ductal adenocarcinoma via the deregulation of IL6. PMID: 27489361
13. Results show that MMP-9 modulates cholesterol metabolism, at least in part, through a novel MMP-9-plasma secreted phospholipase A2 axis that affects the hepatic transcriptional responses to dietary cholesterol. Furthermore, the data suggest that dysregulation of the MMP system can result in metabolic disorder, which could lead to atherosclerosis and coronary heart disease. PMID: 27694328
14. early MMP-9 inhibition delayed inflammation resolution and exacerbated cardiac dysfunction, highlighting the importance of using translational approaches in mice. PMID: 27746126
15. Study identifies the tumor suppressor role of epithelial derived-MMP9 in colitis associated cancer via novel mechanistic pathway "MMP9-Notch1-ARF-p53 axis" regulating apoptosis, cell-cycle arrest and DNA damage. PMID: 27861153
16. Myocardial MMP-9 inhibition prevents ventricular arrhythmia through pleiotropic effects, including the modulation of calcium homeostasis and reduced calcium leakage. PMID: 27966586
17. These results show that MMP-9/TIMP-1 system disturbance and changes of histological structure in uteri tissue are involved in fluoride-induced reproductive dysfunctions. PMID: 28064417
18. IL-33-induced MMP-9 expression in the mouse monocyte/macrophage line RAW264.7. PMID: 28105703
19. MMP-9's contribution to development of atherosclerotic lesions may be a direct stimulation of endothelial cells, and that PAR-1 may serve as a receptor for MMP-9. PMID: 28166283
20. our findings demonstrate that MMP9 is important for tooth development and DSP is a novel target of MMP9 during dentinogenesis. PMID: 28195206
21. analysis of Foxn1 and Mmp-9 expression in the intact and postinjured skin of young, adult, and old C57BL/6J and transgenic Foxn1::Egfp mice PMID: 28371152
22. MMP-9 deficiency augmented AngII-induced Abdominal Aortic Aneurysms. PMID: 28420827
23. The MURC/Cavin-4 in vascular smooth muscle cells modulates abdominal aortic aneurysm (AAA) progression at the early stage via the activation of JNK and MMP-9. MURC/Cavin-4 is a potential therapeutic target against AAA progression. PMID: 28433630
24. PARP-1, via manipulating the binding of NF-kB/AP-1 at the MMP-9 promoter, regulates MMP-9 expression, which helps maintain mitochondrial homeostasis. PMID: 28478229
25. results first identified the role of SNX10 in MMP9 trafficking and secretion, and provided an evidence for SNX10 as a possible therapeutic target for bone destructing disease. PMID: 28498635
26. M. tuberculosis infection caused enhanced MMP-1, -9, and miR-223 expression, with inhibited BMAL1 expression. MiR-223 modulated BMAL1 expression via the direct binding of BMAL1 3'-UTR. PMID: 28543681
27. Study in inflammatory bowel disease (IBD) Mmp-9 knock-out mice model found no differences in clinical or histopathological parameters after genetic or pharmacological inhibition of MMP-9. Therefore suggesting that MMP-9 upregulation is a consequence of the inflammatory process and unlikely represents a therapeutic target in IBD. PMID: 28561062
28. omega-3 reduces MMP-9 gene expression and improves myoblast engraftment, satellite cell activation, and muscle regeneration by mechanisms involving, at least in part, the regulation of macrophages. PMID: 28623422
29. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion PMID: 28794159
30. Thus, the light reintroduction-induced increase in MMP-9 removes constraints on structural and functional plasticity in the mature cortex. PMID: 28875930
31. A MMP-9-cleaved OPN fragment, OPN-32kDa, was responsible for inducing expansion of myeloid-derived suppressor cells, which may contribute to 3LL tumor's evasion of the immune response. PMID: 28986261
32. These results indicated that MMP-9/2 activation in spinal microglia plays a key role in incision-induced mechanical allodynia in mice. PMID: 29081070
33. Studied effects of hesperidin on skin photoaging in a hairless mouse model; results showed that hesperidin inhibited the MMP-9 related signaling pathway activated by UVB irradiation. PMID: 29382339
34. fracture union in matrix metalloproteinase 9 deficient mice PMID: 29851987
35. The findings support the correlation between age-related hearing loss and cognitive decline in C57BL/6J mice, and indicated that MMP9 expression in the auditory cortex and hippocampus may be associated with the underlying mechanisms. PMID: 29901198

KEGG: mmu:17395

STRING: 10090.ENSMUSP00000017881

UniGene: Mm.4406

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays):CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

To assess the linearity of the assay, samples were spiked with high concentrations of mouse MMP-9 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.