1. Flt-1 appears to play a role in oxidative stress, which promotes apoptosis of trophoblasts PMID: 26203176
2. FLT1 inhibition reduces tumor metastatic efficiency even after initial seeding, suggesting that these pathways represent therapeutic targets in metastatic disease. PMID: 26261265
3. This article reviews the current evidence on the clinical utility of the sFlt-1/PlGF ratio at different points in pregnancy and, accordingly, make a proposal for its clinical implementation. [review] PMID: 26287164
4. data suggest that sFlt-1 may have a therapeutic effect on AS, resulting from suppression of VEGF signaling-mediated recruitment of circulating monocytes/macrophages PMID: 26600037
5. Circulating sFlt-1 is generated as a result of myocardial injury and subsequent heart failure development. PMID: 26699385
6. the VEGFR-1 tyrosine kinase signaling has an effect on angiogenesis. PMID: 26898435
7. IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor and its receptors PMID: 26922678
8. These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B to VEGFR1. PMID: 26928042
9. these results suggest that VEGFR1 signaling plays a role in regulating the balance between macrophage phenotypes in streptozotocin -induced diabetic wounds, prevents impaired diabetic wound healing, and promotes angiogenesis/lymphangiogenesis. PMID: 27085138
10. Flt1/VEGF-A signalling has stage-specific effects on vascular morphogenesis. PMID: 27142980
11. Results show that Flt1 heterozygosity causes embryonic edema with enhanced vascular permeability. It can also be a risk factor for embryonic lethality in combination with other mutations causing non-lethal vascular phenotype. PMID: 27251772
12. endothelial dysfunction due to high circulating sFLT1 may be the primary event leading to enhanced vasoconstrictor sensitivity that is characteristic of preeclampsia PMID: 27270170
13. First-in-class selective PET tracers for imaging VEGFR-1 and VEGFR-2 were constructed and successfully validated in an orthotopic murine tumor model. PMID: 27390161
14. sFlt-1 overexpression in Padi4(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation. PMID: 28007693
15. Esomeprazole decreased blood pressure in a transgenic mouse model where human sFlt-1 was overexpressed in placenta. PPIs upregulated endogenous antioxidant defenses and decreased cytokine secretion from placental tissue and endothelial cells. PMID: 28115513
16. Flt1 has a role in blood vessel anastomosis during angiogenesis PMID: 28246215
17. Motor neurons control blood vessel patterning by an autocrine mechanism that titrates motor neuron-derived VEGF via their own expression of sFlt1. PMID: 28262664
18. This is the first report demonstrating the spatiotemporal expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after MI; thus, this study suggests that these factors have distinct and important functions in coronary angiogenesis. PMID: 29158084
19. excessive sFlt1 and lack of eNOS synergistically induce hepatic dysfunction and thrombocytopenia, suggesting a novel role for VEGF and nitric oxide signaling in hepatocyte-endothelial cross-talk in health and in liver injury states. PMID: 29311569
20. Our study suggests that "migration" of the placenta is derived from placental degeneration at the caudal part of the placenta, and sFlt-1 plays a role in this placental degeneration. PMID: 29409879
21. inducible endothelial genetic deletion of Neuropilin1 (Nrp1) and Vascular endothelial growth factor receptor 1 (Vegfr1; also known as Flt1) renders mice resistant to diet-induced obesity. PMID: 30093598

KEGG: mmu:14254

STRING: 10090.ENSMUSP00000031653

UniGene: Mm.389712