1. Western blot analysis confirmed strong CD154 expression in the cultured cell line PC10, but not in LK2. We also assessed CD154 expression in SCID mouse xenografts of these cell lines. PMID: 23404288
2. Propose a role of MMP-9 in regulating platelet-dependent infiltration of neutrophils and tissue damage in septic lung injury by controlling CD40L shedding from platelets. PMID: 23617547
3. A major part of central and effector memory CD8(+) T cells expresses CD40L, one key molecule for CD4(+) T-cell-mediated help. PMID: 23719298
4. Protein kinase C zeta is critically required for sCD40L-induced Mac-1 activation and neutrophil adhesive function. PMID: 23785403
5. expression of CD40L in an earlier developmental step may be determinant in the regulation of the class switch recombination process PMID: 24030045
6. Preexisting autoreactive T cells specific for cardiac myosins are important functional barriers to donor specific transfusion/anti-CD154 antibody induced prolongation of cardiac allograft survival in mice. PMID: 24056628
7. many ATII-induced effects on vascular dysfunction, such as vascular inflammation, oxidative stress and a pro-thrombotic state, are mediated at least in part via CD40L. PMID: 24061433
8. These data indicate that the ability of autoreactive CD4(+) T cells to undergo tolerance mediated by CD8(+) dendritic cells is defective in NOD mice and that blocking CD40-CD40L interactions can restore tolerance induction. PMID: 24082013
9. in vivo biochemical or genetic inhibition of NFATc2 activity in megakaryocyte diminishes platelet CD40L implicates the NFATc2/EGR-1 axis as a key regulatory pathway of inflammatory and immunomodulatory activity in platelets PMID: 24106272
10. data show that vaccination with TAA/CD40L DNA can induce potent antitumor effects against TAA-expressing tumors through the generation of better functioning antigen-specific CD8+ T cells. PMID: 24664420
11. Key contributions of CD40L and IFNG signaling in the antitumor responses triggered in vivo by B-Raf(V600E) inhibitors. PMID: 24736544
12. CD154 expression by CD4 T cells is required for the priming memory CD8 T cells that are capable of fully responding to secondary infection. PMID: 24777309
13. Data indicate that a single dose of adenoviral vectors secreting nucleoprotein (NP)-CD40L fusion protein (rAd-SNP40L) completely protected mice from lethal viral challenge 4 mo after immunization. PMID: 24928989
14. findings indicate that targeting Rac1 signaling might be a useful way to control pathologic elevations of CD40L in the systemic circulation in abdominal sepsis PMID: 25046439
15. Platelets promote allergic asthma through the expression of CD154. PMID: 25418472
16. Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases. PMID: 25839125
17. The tissue-specific, activation-dependent and reversible expression of CD40L fully mimics the physiological induction and disappearance of the molecule from the surface of murine T lymphocytes. PMID: 26223487
18. PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development. PMID: 26363052
19. our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8(+) T-cell responses also under inflammatory conditions, CD40L expression by CD8(+) T cells themselves is dispensable in acute lymphocytic choriomeningitis virus infection. PMID: 27562840
20. studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 signaling PMID: 28461568
21. These results suggest that combination of IL-21, anti-Tim1 and CD40L treatment induced B10 cell's IL-10 competency in vitro and inhibited periodontal bone loss in ligature-induced experimental periodontitis. PMID: 28583714
22. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis. PMID: 29155846
23. MR1-induced bone accrual was associated with increased Treg development and elevated production of cytotoxic T lymphocyte antigen 4, a costimulation inhibitor that promotes T cell anergy and CD8+ T cell expression of the bone anabolic ligand Wnt-10b. PMID: 29522194

KEGG: mmu:21947

STRING: 10090.ENSMUSP00000033466

UniGene: Mm.4861