1. we report that estradiol has minimal direct actions on LepRb cells in the mediodasal hypothalamus and that its anorexigenic effects can occur entirely independently of LepRb-STAT3 signaling in female mice. PMID: 26937712
2. This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals. PMID: 26990203
3. Leptin/LepR signaling regulates adipogenesis and osteogenesis by mesenchymal stromal cells in the bone marrow in response to diet and adiposity. PMID: 27053299
4. These mice showed an increase in FSH levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice. PMID: 27101301
5. LepRb preoptic area neurons are stimulatory glutamatergic neurons, contrary to prevalent models PMID: 27147656
6. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus. PMID: 27283954
7. Leptin expression is regulated by DNA methylation in adipocytes. PMID: 27494408
8. Data suggest that hypothalamic leptin/leptin receptor signaling plays a critical role in neurodevelopment, sympathetic activation, and prevention/development of hypertension. [REVIEW] PMID: 27613336
9. leptin/ObRb-mediated signals were enhanced in hypothalamus of GD3S KO mice due to increased a-series gangliosides, leading to the apparently similar features of energy expenditure between the KO and wild type mice PMID: 27644882
10. HFD-induced lipotoxicity and deregulated organelle biosynthesis confer cancer stem cell-like properties to the gastric mucosa via signaling pathway mediated by the leptin receptor, leptin, PI3K and beta-catenin PMID: 27693038
11. Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1). PMID: 27941793
12. Leptin receptors on agouti-related peptide neurons modulate the onset of puberty and adult fertility. PMID: 28275162
13. Neurotensin-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors. PMID: 28323938
14. Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA signalling could be an effective way to treat bone marrow fibrosis. PMID: 28481328
15. Knockin of Lepr in beta cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia. PMID: 28580288
16. Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake. PMID: 28938472
17. Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model. PMID: 29430464
18. Abnormal sex hormone levels of Y123F mice were due to not only decreased gonadotropin levels in the central nervous system, but also ovarian hormone synthase abnormalities in the peripheral gonads. PMID: 29728128

KEGG: mmu:16847

STRING: 10090.ENSMUSP00000037385

UniGene: Mm.259282