1. E- and P-selectins have a crucial role in spontaneous metastasis formation. PMID: 20010946
2. The signaling pathway downstream of Syk divides into PLC2- and PI3K-dependent pathways. The activation of these pathways is controlled by the Tec family kinase Btk, which is required for E-selectin-mediated slow rolling. PMID: 20167705
3. E-selectin triggers common signals through distinct neutrophil glycoproteins to induce alpha(L)beta(2)-dependent slow rolling PMID: 20299514
4. Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4 PMID: 20368416
5. core 1-derived O-glycans are essential E-selectin ligands, while PSGL-1, CD44, and ESL-1 do not constitute all glycoprotein ligands for E-selectin. PMID: 20439727
6. Immature mast cells can undergo a tightly regulated extravasation cascade consisting of rolling on and adhesion to endothelium and followed by directed diapedesis and reveal E-selectin, P-selectin, VCAM-1 and PECAM-1 as required adhesion molecules. PMID: 20507363
7. No major differences were identified between ICAM-1 and E-selectin expression in varicose vein specimens compared with controls. PMID: 20632821
8. E-selectin and P-selectin mediate the recruitment of reperfusion-induced bone marrow stromal cells to the infarct site and enable their adhesion to the cerebral microvasculature following ischemia. PMID: 21257828
9. Localized activation of endothelial FAK and E-selectin in the lung vasculature mediates the initial homing of metastatic cancer cells to specific foci in the lungs. PMID: 21321210
10. Primary subcutaneous growth of B16 melanoma was augmented by loss of PSGL-1, P-selectin, or E-selectin, while pulmonary metastasis was reduced by the loss of E-selectin. PMID: 21889879
11. Data show that the protective effect of hydroxyurea was abrogated in mice deficient in E-selectin. PMID: 22130804
12. the up-regulation of P-selectin, E-selectin and intercellular adhesion molecule-1 contributes to the increased leucocyte rolling flux, reduced leucocyte rolling velocity, and increased leucocyte adhesion, respectively. PMID: 22681228
13. E-selectin deficiency presents a protective effect on cerebral ischemia, likely achieved by the inhibition of inflammation and apoptosis. PMID: 22978829
14. Constitutively expressed E-selectin on endothelial cells in the proliferating phase is one mediator of the stem cell tropism in infantile hemangioma. PMID: 23041613
15. transient blockade of E-selectin is potentially a promising treatment for the protection of HSCs during chemotherapy or irradiation PMID: 23086476
16. beta(3)-adrenergic stimulation acts through up-regulation of E-selectin in adipose tissue endothelial cells to induce neutrophil infiltration PMID: 23235150
17. TWEAK acted as an inducer of E-selectin and ICAM-1 expression in mice with cutaneous vasculitis and human dermal microvascular endothelial cells PMID: 23457623
18. Expression of E-selectin is sufficient to support rescue & hematopoietic reconstitution of lethally irradiated recipients forllowing bone marrow transplant. PMID: 23499761
19. Elevated E-selectin plays an important role in hepatic neutrophil infiltration and injury induced by chronic-binge feeding in mice and may also contribute to the pathogenesis of early stages of human alcoholic liver disease. PMID: 23532958
20. expression of E-selectin and ICAM-1 are suppressed by paeoniflorin in a mouse model of cutaneous Arthus reaction PMID: 23800055
21. The study suggest that E- and P-selectins play an important role in leukemic dissemination in chronic myelogenous and chronic eosinophilic leukemias. PMID: 23922938
22. The histopathological modification of lupus nephritis by non-nephritogenic bystander IgM antibodies is associated in part with glomerular E-selectin expression. PMID: 24372297
23. involved in neutrophil recruitment into the kidney after induction of sepsis PMID: 24576991
24. Systemic inflammation may increase the expression of E-selectin which mediated the lung metastasis of breast cancer in mouse model. PMID: 24658642
25. In the absence of either PSGL-1 or E- and P-selectin. PMID: 24740164
26. Regulatory T cells dynamically regulate P and E selectin ligand expression during multiple challenge contact hypersensitivity. PMID: 25274531
27. Data show that actin cytoskeleton regulated CD44 membrane mobility and interactions with E-selectin. PMID: 25359776
28. Complex spatiotemporal expression dynamics of selectins determine the sequential extravasation of neutrophils and inflammatory monocytes in the acute inflammatory response. PMID: 25722429
29. In a model of corneal transplantation, P- and E-selectin mediate T cell recruitment to the graft, E-selectin mediates APC trafficking to lymphoid tissue, and blockade of E-selectin has a modest effect on improving long-term graft survival. PMID: 26910325
30. Inhibiting E-selectin attenuated inflammation in atherosclerotic plaques, likely by reducing leukocyte recruitment into plaques and by mitigating hematopoietic stem and progenitor cell activation in the spleen of mice with myocardial infarction. PMID: 27470513
31. Before the arrival of tumor cells, the lung-recruited monocytic myeloid-derived suppressor cells produced IL-1beta, thereby increasing E-selectin expression and promoting tumor cell arrest on endothelial cells. PMID: 27885671

KEGG: mmu:20339

STRING: 10090.ENSMUSP00000027874

UniGene: Mm.5245