1. GP130/STAT3 pathway is activated in NAFLD and can worsen insulin resistance while protecting against other lipotoxic mechanisms of disease pathogenesis. PMID: 25747354
2. Mutations leading to constitutive active gp130/JAK1/STAT3 pathway. PMID: 26188635
3. Diabetic rats show an increase in the contractions of distal colon partly via the IL-6-IL-6 receptor pathway. PMID: 26191141
4. pulmonary exposure to MWCNT can manifest as a reduced epithelial barrier and activator of vascular gp130-associated transsignaling that may promote susceptibility to cardiovascular derangements PMID: 26589480
5. High serum GP130 levels were associated with Chronic Spontaneous Urticaria. PMID: 26699882
6. In the present study, we analyze the role of a unique cysteine residue (Cys-628) within this C-terminus, which is contained neither in the membrane-bound gp130 nor in the two other sgp130 forms. PMID: 26809098
7. we developed a CRISPR-Cas9-based tool for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation of a wider promoter region of the target loci IL6ST and BACH2 decreased their expression PMID: 26969735
8. Intracellular p19 associated with the cytokine receptor subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3) signaling PMID: 26980441
9. This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease. PMID: 27053713
10. age 3 plasma levels of sGP130 were found related to childhood asthma PMID: 27434124
11. an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation. PMID: 27489351
12. gp130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer. PMID: 27917904
13. Data show that tumor suppressor adenomatous polyposis coli (APC) loss results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating YAP (YY1-associated) protein (YAP) which are simultaneously up-regulated in the majority of colorectal cancer (CRC). PMID: 28130546
14. GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. PMID: 28356514
15. SNP rs10940495 in the gp130 locus was associated with functional outcome at 6 months following spontaneous intracerebral hemorrhage. PMID: 28964648
16. Low levels of serum sgp130 were positively associated with sex hormones in male patients with coronary artery disease, suggesting an important role of sgp130 in the presence of low and imbalanced sex hormones levels. PMID: 29028483
17. Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130. PMID: 29038846
18. we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex. PMID: 29237553
19. Low soluble glycoprotein 130 (sgp130) level may serve as an additional indicator of coronary atherosclerosis severity. PMID: 29580104

HGNC: 6021

OMIM: 600694

KEGG: hsa:3572

STRING: 9606.ENSP00000338799

UniGene: Hs.532082