1. Results show that Lnc RNA BDNF-AS inversely regulates the expression level of BDNF which modulates high-glucose induced apoptosis in human retinal pigment epithelial cells. PMID: 28657668
2. This study shows the genetic correlates of early trauma in a group of schizophrenia patients (BDNF Met carriers). PMID: 28711474
3. that the BDNF SNP rs1157659 interacted with mild traumatic brain injury to predict hippocampal volume PMID: 28755387
4. polymorphisms in BDNF gene including rs925946, rs10501087, rs6265 and rs988712 can be considered as genetic determinants of obesity (systematic review and meta-analysis). PMID: 28818748
5. This study show a linear relationship between the BDNF Val66Met genotypes and plasma BDNF levels in Caucasian depressed patients. PMID: 28848102
6. the BDNF Val66Met polymorphism is associated with functional tuning of behaviorally-relevant frontolimbic circuitry, particularly involving the ventromedial prefrontal cortex, during higher-order learning. PMID: 28867340
7. BDNF/TrkB axis plays a role in epithelial mesenchymal transition promoting the acquisition of (myo)fibroblast cell phenotype in idiopathic pulmonary fibrosis. PMID: 28938915
8. Study shows that brain-derived neurotrophic factor concentrations in serum and peritoneal fluid were significantly higher in women with endometriosis with pain compared to women with endometriosis without pain. PMID: 28954602
9. Met allele of the Val66Met polymorphism in brain derived neurotrophic factor is associated with lower BMI-SDS in children PMID: 28960774
10. This study showed that in first-episode psychosis subjects, with global DNA hypo-methylation and reduced BDNF gene-expression. PMID: 29056292
11. found evidence that supported the hypothesis that BDNF Val66Met polymorphism moderated the relationship between stress and depression. PMID: 29102837
12. Meta-analysis/Review: patients with ischemic stroke at high risk of post stroke depression have lower BDNF levels at the early stage of stroke. PMID: 29128330
13. found that though there was no significantly difference in peripheral BDNF levels between ADHD patients and control groups overall, BDNF levels were significantly higher in males with ADHD compared with controls. PMID: 29132072
14. This study demonstrated that a significantly higher incidence of defective BDNF expression in granule layers of the cerebellar cortex. PMID: 29174061
15. MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting BDNF. PMID: 29257320
16. There was a statistically significant change in BDNF levels post-chemotherapy in early-stage breast cancer patients, and plasma BDNF levels were associated with self-perceived concentration deficit in patients receiving chemotherapy. PMID: 29258453
17. BDNF rs11030101 and BDNF rs61888800are associated with change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment. PMID: 29310728
18. The functional Val66Met BDNF polymorphism is not associated with BDNF serum levels in acute episode of schizophrenia and depression. PMID: 29331787
19. High expression levels of BDNF was observed in cervical cancer.BDNF role in epithelial-mesenchymal transition, migration and invasion of cervical cancer. PMID: 29345295
20. Serum BDNF was significantly lower in patients with Parkinson's disease than in patients with essential tremor and controls. PMID: 29350074
21. Our study provides evidence for the correlation between the BDNF variant rs6265 and emotional symptoms in the early phase after mild traumatic brain injury. PMID: 29357818
22. Study suggested that BDNF 196 G>A polymorphism may be a genetic marker for predicting insulin resistance before initiating risperidone treatment in autism spectrum disorder patients. PMID: 29369497
23. In a 12-year longitudinal population-based sample of older adults (n = 2,218), we used growth curve modeling to investigate whether the benefits of physical activity on cognitive preservation differed by BDNF genotype and sex across multiple cognitive domains including processing speed, attention, working memory, and episodic verbal memory. PMID: 29402782
24. Coronary artery disease patients exhibited significantly lower plasma BDNF and higher vWF levels than those of control patients. PMID: 29409455
25. No significant difference was found in the BDNF Val66Met polymorphism between patients with GAD and healthy controls, nor was this polymorphism significantly associated with antidepressant drug efficacy for GAD PMID: 29446659
26. Review/Meta-analysis: suggests a lower risk of ischemic stroke for the GG genotype of BDNF rs6265. PMID: 29449128
27. The results of this study suggest that the Val66Met polymorphism does not predict long-term, functional mobility following stroke. PMID: 29480080
28. Low brain derived neurotrophic factor may contribute to the pathogenesis of schizophrenia, but maybe not to its cognitive impairments. PMID: 29482040
29. Its single-nucleotide polymorphisms involves in dopaminergic metabolism and motor and cognitive function in older adults. PMID: 29525179
30. Angiogenin contributes to angiogenesis induced by Brain-derived neurotrophic factor (BDNF). PMID: 29573867
31. The sample consisted of 181 suicide cases (47 early suicide cases, 134 late suicide cases) and 162 controls. Patients with the BDNF Met allele had a 1.42-fold increased risk of suicide when compared with the Val allele carrier. When a suicide case is stratified by occurrence time, patients with the Met/Val or Met/Met genotype had a 2.48-fold increased risk of committing suicide early than those with the Val/Val genotype. PMID: 29734216
32. Neurotrophic factors and hippocampal activity in PTSD PMID: 29799860
33. combining cognitive and physical exercise had no additional or synergistic effect on peripheral BDNF levels compared with physical exercise alone PMID: 29842831
34. while the BDNF Val66Met Megroup displayed significant SICI reduction in the bilateral M1 in response to motor training, short-interval intracortical inhibition (SICI) remained unchanged in the BDNF Val66Met group. PMID: 29856758
35. serum BDNF levels and the BDNF Val66Met polymorphism in healthy young adults were associated with the sleep pattern on weekends but not with that on weekdays, suggesting that the systems involved in BDNF control may be linked to endogenous sleep characteristics rather than the socially constrained sleep schedule in healthy young adults. PMID: 29944703
36. Findings demonstrated that polymorphism Val66Met is not associated with temporal lobe epilepsy caused by hippocampal sclerosis, epilepsy-related factors and psychiatric comorbidities in this selected group of patients. PMID: 30015148
37. platelet BDNF and SERT do not specifically underlie psychosocial deficits in stage Huntington's Disease, while higher BDNF storage in delayed mild symptoms PMID: 30039833
38. These results indicate that genetic variant Met66 decreased the serum BDNF levels in combination with self-reported risk-taking propensity among heroin users. PMID: 30134233
39. This study demonstrated significant differences in the blood levels of BDNF between people with epilepsy and healthy subjects. PMID: 30140987
40. Mn-SOD V allele carries a worse outcome profile after stroke, relating to nitrosative stress, inflammatory, and apoptotic response and associated with a BDNF reduction. PMID: 30150066

HGNC: 1033

OMIM: 113505

KEGG: hsa:627

STRING: 9606.ENSP00000414303

UniGene: Hs.502182