N-Benzyl-N-demethylpronqodine A (Indoleamine 2,3-dioxygenase (IDO) inhibitor)

                                                                                                        


Cat.No: FNK-17787

Size: 1 mg

Storage: -20℃

Molecular Weight: 270.306

Purity:>98% (HPLC)

CAS#:1810092-90-0

Molecular Formula: C14H10N2O2S

Source: Chemically synthesized

Appearance:Powder

Solubility:Soluble in MeOH, DMSO, Insoluble in Hexane


The chemical structure was confirmed by NMR and HRMS.
 

Application

N-Benzyl-N-demethylpronqodine A inhibited the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO) much potent than pronqodine A. ^1,2) They were good substrates for NAD(P)H quinone oxidoreductase 1 (NQO1) and were rapidly reduced to unstable hydroquinones that spontaneously undergo autoxidation back to the parent quinone.^1,2)
 

References

1) NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactitivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells. Nakae K, et al. J Nat Prod. 2013 76(4) 510-515.

2) Synthesis and intracellular redox cycling of natural quinones and their analogues and identification of indoleamine-2,3-dioxygenase (IDO) as potential target for anticancer activity. Blunt CE, et al. Angew Chem int Ed. 2015 54(6) 8740-8745.