Molecular Weight: 584.526 (as sodium salt of the hydrolysate)
Purity: >90% (HPLC, containing hydrolysate)
CAS#: 1155308-84-1 (as anhydride form)
Molecular Formula: C26H34O11•Na2O (as sodium salt of the hydrolysate)
Source: Penicllium sp.
Appearance: Powder
Solubility: Soluble in H2O
The chemical structure was confirmed by NMR and HRMS.
Application
Ceramidastin was isolated from culture filtrate of Penicillium sp. Mer-f17067.1 It inhibited Peudomonas ceramidase with IC50 value of 6.25 μg/ml.1But it did not inhibit human ceramidase at 200 μg/ml.1) Mouse model of atopic dermatitis showed the increase of mast cells in the dermis by Peudomonas ceramidase application. Ceramidastin significantly inhibited the increase of mast cells.1 When ceramidastin was administered to mice intravenously, no fatality was observed up to 6.25 mg/kg.1) The maleic anhydride moieties of ceramidastin react with water to form the corresponding dicarboxylic acid. Our ceramidastin is supplied as the sodium salt of the hydrolysate form, which has better solubility in water.
References
1) Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicilliumsp. Mer-f17057. Inoue H, et al. J Antibiot. 2009 62(1) 63-67.
