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Anti-MMP13 Rabbit Polyclonal Antibody (IHC, IF)

Product#: SB-GB11247

$560.00

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Anti-MMP13 Rabbit Polyclonal Antibody (IHC, IF)

General information

Cat. No.	：SB-GB11247
Size	：100 uL
Protein full name	：Collagenase 3
Synonym	：Collagenase 3, MMP13, CLG3, MANDP1, MMP-13, Matrix metallopeptidase 13, MDST
Immunogen	：KLH conjugated Synthetic peptide corresponding to Mouse MMP13
Isotype	：IgG
Purity	：Affinity purification
Subcellular location	：Secreted
Uniprot ID	：P33435, P23097
Long Term Storage	：-20 ℃ or below
Shipping Condition	：Dry Ice
Storage Buffer	：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.

Application

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 200	bone
IF	Mouse, Rat	1: 200	bone

Description

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

	Immunohistochemistry analysis of paraffin-embedded rat bone using MMP13 (GB11247) at dilution of 1:200
	Immunohistochemistry analysis of paraffin-embedded mouse bone using MMP13 (GB11247) at dilution of 1:200

Antigen Characterization

Type: Primary
Application: ELISA,Western Blot,Immunohistochemistry (IHC),Immunoprecipitation (IP)
Species: Human, Mouse, Rat, Rabbit
Recombinant: Yes

Human Diseases

Spondyloepimetaphyseal Dysplasia, Missouri Type: A genetic disorder affecting bone growth and development.
Metaphyseal Anadyplasia 1: A skeletal dysplasia characterized by short stature and skeletal abnormalities.
Metaphyseal Dysplasia, Sphar Type: Another form of skeletal dysplasia affecting bone morphology and growth.

Cellular Signaling Pathways

Wnt Signaling Pathway: MMP13 is involved in the degradation of extracellular matrix components, influencing cell signaling related to development and tissue remodeling.
TGF-β Signaling Pathway: MMP13 can modulate TGF-β activity, which is crucial for various cellular processes including proliferation and differentiation.
Integrin Signaling: MMP13 interacts with integrins, affecting cell adhesion and migration during wound healing and tissue repair.

Aliases for MMP13 Gene

GeneCards Symbol: MMP13 ²
Matrix Metallopeptidase 13 ²³⁵
Collagenase 3 ²³⁴
CLG3 ²³⁵
Matrix Metalloproteinase 13 (Collagenase 3) ²³
MMP-13 ³⁴
Matrix Metalloproteinase-13 ⁴
EC 3.4.24.35 ⁴⁹
EC 3.4.24.22 ⁴⁹
EC 3.4.24.24 ⁴⁹
EC 3.4.24.65 ⁴⁹
EC 3.4.24.- ⁴
EC 3.4.24.7 ⁴⁹
EC 3.4.24 ⁴⁹
MANDP1 ³
MDST ³

References

Duncan, Henry F., et al. “The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair through the Wnt Signaling Pathway.” Frontiers, Frontiers, 14 Mar. 2022, www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.883266/full.
Wang, Meina, et al. “MMP13 Is a Critical Target Gene during the Progression of Osteoarthritis - Arthritis Research & Therapy.” BioMed Central, BioMed Central, 8 Jan. 2013, arthritis-research.biomedcentral.com/articles/10.1186/ar4133.
MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem | 444283, www.merckmillipore.com/INTL/en/product/MMP-13-Inhibitor-CAS-544678-85-5-Calbiochem,EMD_BIO-444283.
Kumar, Purushottam, et al. “The Role of Matrix Metalloproteinase 13 and Vitamin D in Osteoarthritis: A Hospital-Based Observational Study.” Cureus, U.S. National Library of Medicine, 18 Sept. 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10582788/.
A, Oranger, et al. “Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing.” (MA5-14238), www.thermofisher.com/antibody/product/MMP13-Antibody-clone-VIIIA2-Monoclonal/MA5-14238.