Anti-MEK2 Rabbit Polyclonal Antibody
Anti-MEK2 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB111018 |
| Size | ：100 uL |
| Protein full name | ：Dual specificity mitogen-activated protein kinase kinase 2 |
| Synonym | ：MAP kinase kinase 2, Prkmk2 ,Mek2, Mkk2, Map2k2, ERK activator kinase 2, MAPK/ERK kinase 2, MAPKK 2, PRKMK 2, PRKMK2 V |
| Immunogen | ：Recombinant protein corresponding to Mouse MEK2 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Cytoplasm |
| Predicted MW. | ：44KDa |
| Observed MW. | ：48KDa |
| Uniprot ID | ：P36507, Q63932, P36506 |
| Long Term Storage | ：-20 ℃ or below |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung, brain |
| IHC/IF | Mouse, Rat | 1: 500-1: 2000 | brain, lung, spleen |
Description
MAP kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
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Western blot analysis of MEK2 (GB111018) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded mouse brain using MEK2 (GB111018) at dilution of 1: 2000 (350x lens) |
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Immunohistochemistry of paraffin embedded mouse brain using MEK2 (GB111018) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using MEK2 (GB111018) at dilution of 1: 2000 (400x lens)
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Immunohistochemistry of paraffin embedded rat lung using MEK2 (GB111018) at dilution of 1: 2000 (400x lens)
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Immunohistochemistry of paraffin embedded rat spleen using MEK2 (GB111018) at dilution of 1: 2000 (400x lens)
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- Type: Primary
- Application: Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence
- Species: Human, Mouse, Rat, Canine, Monkey
- Recombinant: Yes
Human Diseases
- Cancer: MEK2 is involved in the MAP kinase signaling pathway, which is often dysregulated in cancer. Inhibition or degradation of MEK2 has been found to be involved in the pathogenesis of Yersinia and anthrax infections.
- Yersinia and Anthrax Infections: The inhibition or degradation of MEK2 is found to be involved in the pathogenesis of Yersinia and anthrax infections
Cellular Signaling Pathways
- MAP Kinase Signaling: MEK2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. It plays a critical role in mitogen growth factor signal transduction by phosphorylating and activating MAPK1/ERK2 and MAPK2/ERK3.
- T-cell Development and Activation: Although the ERK/MAP kinase cascade is known to be involved in T-cell development and activation, MEK2 appears to be nonessential for thymocyte differentiation and T-cell-receptor-induced proliferation and apoptosis
Aliases for MEK2 Gene
- GeneCards Symbol: MAP2K2 2
- Mitogen-Activated Protein Kinase Kinase 2 2 3 5
- MEK2 2 3 4 5
- PRKMK2 3 4 5
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 3 4
- ERK Activator Kinase 2 3 4
- MAP Kinase Kinase 2 3 4
- MAPK/ERK Kinase 2 3 4
- EC 2.7.12.2 4 48
- MKK2 3 4
- Mitogen-Activated Protein Kinase Kinase 2, P45 3
- MAPKK 2 4
- MAPKK2 3
- MEK 2 4
- CFC4 3
References
- MEK2 antibody (ABIN1882178). MEK2 Antibody (ABIN1882178). (n.d.). https://www.antibodies-online.com/antibody/1882178/anti-Mitogen-Activated+Protein+Kinase+Kinase+2+MAP2K2+AA+1-30,+N-Term+antibody/
- MEK2 antibody (OTI1A2), PE, novus biologicals - antibodies, primary antibodies. Fisher Scientific - part of Thermo Fisher Scientific. (n.d.-c). https://www.fishersci.nl/shop/products/mek2-antibody-oti1a2-pe-novus-biologicals/30028039
- Cell Signaling Technology. “Mek2 Antibody.” Cell Signaling Technology, www.cellsignal.com/products/primary-antibodies/mek2-antibody/9125.
- Bélanger, Louis-François, et al. “Mek2 Is Dispensable for Mouse Growth and Development.” Molecular and Cellular Biology, U.S. National Library of Medicine, July 2003, www.ncbi.nlm.nih.gov/pmc/articles/PMC162209/.
- MEK-2 Antibody: SCBT - Santa Cruz Biotechnology.” SCBT, www.scbt.com/browse/mek-2-antibodies.
