Anti-MS4A2 Rabbit Polyclonal Antibody
Product#: SB-GB112640
$779.20
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Anti-MS4A2 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112640 |
| Size | ：100 uL |
| Protein full name | ：High affinity immunoglobulin epsilon receptor subunit beta |
| Synonym | ：FcERI, Fc epsilon receptor I beta-chain, IgE Fc receptor subunit beta, Membrane-spanning 4-domains subfamily A member 2, Ms4a2, Fce1b, Fcer1b, Ms4a1 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse MS4A2 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：26 kDa |
| Observed MW. | ：24 kDa |
| Uniprot ID | ：P20490, P13386 |
| Long Term Storage | ：-20 ℃ or below |
| Shippping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse, Rat | 1: 500-1: 1000 |
liver, brain |
Description
This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins.
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Western blot analysis of MS4A2 (GB112640) at dilution of 1: 1000 Lane 1: Mouse liver tissue lysate Lane 2: Mouse brain tissue lysate Lane 3: Rat liver tissue lysate Lane 4: Rat brain tissue lysate |
Antigen Characterization
- Type: Primary
- Application: ELISA,Western Blot,Immunohistochemistry (IHC),Immunocytochemistry (ICC)
- Species: Human
- Recombinant: Yes
Human Diseases
- Atopic Asthma: Associated with IgE responsiveness, influencing allergic reactions and asthma severity.
- Allergic Rhinitis: Implicated in the pathogenesis of allergic rhinitis.
- Mast Cell Disorders: Plays a role in mast cell activation and degranulation, contributing to various allergic diseases.
Cellular Signaling Pathways
- FcεRI Signaling Pathway: MS4A2 is a component of the high-affinity IgE receptor (FcεRI), crucial for mast cell activation upon allergen exposure.
- Cytokine Signaling: Involved in the regulation of cytokine release during immune responses.
- Calcium Signaling Pathway: Activation leads to intracellular calcium mobilization, essential for mast cell degranulation and mediator release.
Aliases for MS4A2 Gene
- GeneCards Symbol: MS4A2 2
- Membrane Spanning 4-Domains A2 2 3 5
- FCER1B 3 4 5
- IGER 3 4 5
- APY 3 4 5
- Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide 2 3
- High Affinity Immunoglobulin Epsilon Receptor Subunit Beta 3 4
- Membrane-Spanning 4-Domains Subfamily A Member 2 3 4
- IgE Fc Receptor Subunit Beta 3 4
- High Affinity Immunoglobulin Epsilon Receptor Beta-Subunit (FcERI) (IgE Fc Receptor, Beta-Subunit) (Fc Epsilon Receptor I Beta-Chain) 3
- Membrane-Spanning 4-Domains, Subfamily A, Member 2 (Fc Fragment Of IgE, High Affinity I, Receptor For; Beta Polypeptide) 2
- Immunoglobulin E Receptor, High Affinity, Beta Polypeptide 3
- Membrane-Spanning 4-Domains, Subfamily A, Member 2 2
- High Affinity IgE Receptor Beta Subunit 3
- Fc Epsilon Receptor I Beta-Chain 4
- IgE Responsiveness (Atopic) 2
- ATOPY 3
- FCERI 3
- IGHER 3
- MS4A1 5
- FcERI 4
- IGEL 3
References
- Anti-MS4A2 Antibody.” Www.Atlasantibodies.Com, www.atlasantibodies.com/products/primary-antibodies/triple-a-polyclonals/anti-ms4a2-antibody-hpa059967/.
- Account - Genecards Suite, www.genecards.org/cgi-bin/carddisp.pl?gene=MS4A2.
- MS4A2 Protein Overview: Sequence, Structure, Function and Protein Interaction | Sino Biological, www.sinobiological.com/resource/ms4a2/proteins.
- MS4A2 - Antibodies - the Human Protein Atlas, www.proteinatlas.org/ENSG00000149534-MS4A2/summary/antibody.
- MS4A2 Membrane-Spanning 4-Domains, Subfamily A, Member 2 [Mus Musculus (House Mouse)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=14126.
