Anti-MYL6 Rabbit Polyclonal Antibody

Product#: SB-GB112598

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Anti-MYL6 Rabbit Polyclonal Antibody

General information

Cat. No.	：SB-GB112598
Size	：100 uL
Protein full name	：Myosin light polypeptide 6
Synonym	：17 kDa myosin light chain, LC17, Myosin light chain 3, MLC-3, Myosin light chain alkali 3, Myosin light chain A3, Smooth muscle and nonmuscle myosin light chain alkali 6, Myl6, Myln
Immunogen	：Recombinant protein corresponding to Mouse MYL6
Isotype	：IgG
Purity	：Affinity purification
Subcellular location	：Cytoskeleton
Uniprot ID	：Q64119
Long Term Storage	：-20 ℃ or below
Shipping Condition	：Dry Ice
Storage Buffer	：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol.

Application

Applications	Species	Dilution	Positive Tissue
IHC	Rat	1: 2000-1: 4000	bladder, heart

Description

Regulatory light chain of myosin. Does not bind calcium.

	Immunohistochemistry analysis of paraffin-embedded rat bladder using MYL6 (GB112598) at dilution of 1: 4000
	Immunohistochemistry analysis of paraffin-embedded rat heart using MYL6 (GB112598) at dilution of 1: 4000

Antigen Characterization

Human Diseases

Microscopic Polyangiitis: MYL6 has been identified as an antigen associated with this autoimmune disease, influencing neutrophil extracellular trap (NET) formation.
Cardiovascular Diseases: Altered expression of MYL6 is implicated in various cardiovascular conditions due to its role in muscle contraction.
Muscle Disorders: MYL6 is essential for normal muscle function and development.

Cellular Signaling Pathways

Muscle Contraction Pathway: MYL6 plays a crucial role in the contraction of skeletal and cardiac muscles through interaction with myosin.
Calcium Signaling Pathway: It is involved in calcium-mediated signaling, which is vital for muscle contraction and relaxation processes.
Regulation of Gene Expression: MYL6 may influence transcriptional regulation in muscle cells.

Aliases for MYL6 Gene

References

Immune Cell - MYL6 - the Human Protein Atlas, Human Protein Atlas, www.proteinatlas.org/ENSG00000092841-MYL6/immune+cell.
Tissue Expression of Myl6 - Summary - The Human Protein Atlas, Human Protein Atlas, www.proteinatlas.org/ENSG00000092841-MYL6/tissue.
Database, Rat Genome. MYL6 (Myosin Light Chain 6) - Rat Genome Database, rgd.mcw.edu/rgdweb/report/gene/main.html?id=1589019.
MYL6 Myosin Light Chain 6 [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=4637.
MYL6B Myosin Light Chain 6b [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=140465.