Anti-Lamin B Receptor antibody, affinity-purified (rabbit polyclonal)

Product#: 70-301
$346.00
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Anti-Lamin B Receptor antibody, affinity-purified (rabbit polyclonal)


General information 

Cat. No. 70-301
Size 50 µg
Antigen Highly purified recombinant mouse LBR (amino acids 1-81)
Antibody Affinity-purified with the recombinant LBR
Host Species Rabbit
Form 1.0 mg/ml in PBS, 50% glycerol
Purification Affinity Purified
Reactivity Mouse and human. Not tested with other species
Application Western blotting (0.2~1 ug /ml)
Immunoprecipitation.
Indirect immuno-fluorescence staining
Other applications were not tested
Storage Shipped at 4℃ or -20℃ and stored at -20℃

Description

Lamins are nuclear membrane proteins that serve to maintain nuclear structure and functions. Lamin B receptor (LBR) is localized in the nuclear envelope inner membrane and anchors the lamina and heterochromatin to the membrane (1). It may mediate interaction between chromatin and lamin B (2). The interaction with lamin and chromatin is regulated by phosphorylation.

 
Figure. Identification of LBR in HeLa cell by immuno-precipitation and immuno-staining with anti-LBR antibody (1-81)

A) Identification of LBR in crude extract of HeLa cells by immuno-precipitation followed by western blotting
B) Indirect immuno-fluorescence staining of HeLa cells
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References
 
1. Worman HJ, et al (1988) A lamin B receptor in the nuclear envelope. Pro.Natl.Acad.Sci. USA 85:8531
2. Pyrpasopoulou A, et al. (1996) The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. EMBO J. 15: 7108-19


Aliases for LBR Gene

  • Lamin B Receptor 2 3 5
  • Integral Nuclear Envelope Inner Membrane Protein 3 4
  • 3-Beta-Hydroxysterol Delta (14)-Reductase 3 4
  • Delta(14)-Sterol Reductase LBR 3 4
  • Tudor Domain Containing 18 2 3
  • C-14 Sterol Reductase 3 4
  • Sterol C14-Reductase 3 4
  • Delta-14-SR 3 4
  • DHCR14B 2 3
  • TDRD18 2 3
  • C14SR 3 4
  • LMN2R 3 4
  • Delta(14)-Sterol Reductase 3
  • Lamin-B Receptor 4
  • EC 1.3.1.70 4
  • PHASK 3
  • PHA 3
  • LBR 5
 
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