Radicicol, 1mg
Product#: FNK-BLK-0500-1mg
$175.41
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Radicicol (1mg)
Cat No: FNK-BLK-0500-1mg
Product ID and Size
| Cat No. | Description | Size | Link |
| FNK-BLK-0500-100μg | Radicicol | 100μg |  |
| FNK-BLK-0500-1mg | Radicicol | 1mg | |
| FNK-BLK-0500-5mg | Radicicol | 5mg | |
Description
Monorden A, which is a macrolactone antibiotic, was isolated from Monosporium bonorden1), Cylindrocarpon radicicola 2), Penicillium luteoorantium3), and other microorganisms. Monorden A binds to Hsp90 (Heat Shock Protein 90) and alters its function4). Monorden A is known as protein kinase inhibitor. Radicicol is an antifungal antibiotic that was shown to inhibit transformation by oncogenes v-src, ras, raf, and mos5, 6).
Origin: Pochonia sp. FKI-4937
CAS Registry Number: 12772-57-5
CA Index Name: 8-Chloro-1α , 14,15,15α - tetrahydro-9,11-dihydroxy-14- methyl-6Hoxireno[e][[2]benzoxacyclotetradecin -6,12(1H)-dione
Appearance: lemon-yellow needles
Molecular Formula/ Weight: C19H17ClO6=364.78
Melting Point: 196-197℃
Purity: >98% by HPLC
Solubility: Sol. MeOH, Chloroform, EtOAc, DMSO Inso. water, Hexane
Handling and Storage: Store at -20℃.
References:
- P. Delmotte & J. Delmotte-Plaque, Nature, 171, 311 (1953).
- W. Evans & N. H. White, Trans. Br. Mycol. Soc., 49, 563 (1966).
- K. Nozawa, S. Nakajima, J. Nat. Prod., 42, 374-377 (1979)
- S. W. Ki, et. al., Biosci. Biotechnol. Biochem., 65, 2528-2534 (2001)
- H. J. Kwon, et. al., Biosci. Biotechnol. Biochem., 56, 538–539 (1992).
- J. F. Zhao, et. al., Oncogene, 11, 161–173 (1995).
