Kaempferol 3-Glucoside

Product#: FNK-2400175
$264.93
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Kaempferol 3-Glucoside






Cat. No.: FNK-2400175


Description

Purity : ?98%

Storage: 4°C





Package Size: 10mg


Human Diseases Affected
 
  • Anti-Cancer Effects
    • Kaempferol 3-Glucoside has shown promising anti-cancer activities against multiple types of cancer:
      • Hepatocellular Carcinoma: It exhibited the highest antiproliferation effect on the human hepatoma cell line HepG2.
      • Colon Cancer: Significant antiproliferative activity was observed against the mouse colon cancer cell line CT26.
      • Melanoma: The compound showed strong effects against the mouse melanoma cell line B16F1.
      • Leukemia: Studies have demonstrated its anticancer potential against leukemia cells (HL-60).
    • The anticancer mechanisms of Kaempferol 3-Glucoside include inhibition of cancer cell proliferation, induction of apoptosis, and cell cycle arrest.
  • Anti-Inflammatory Properties
    • Kaempferol 3-Glucoside possesses potent anti-inflammatory effects, which can be beneficial in treating various inflammation-related diseases:
      • Intervertebral Disc Degeneration: The compound may help alleviate chronic inflammation associated with this condition.
      • Colitis: Its anti-inflammatory properties could be useful in managing inflammatory bowel diseases.
      • Acute Lung Injury: The compound shows promise in treating this acute inflammatory condition.
  • Neuroprotective Effects
    • Kaempferol 3-Glucoside has demonstrated neuroprotective properties, which could be beneficial in managing neurological disorders.
  • Cardioprotective Properties
    • The compound has shown potential in protecting heart function and may be useful in managing cardiovascular diseases.
  • Metabolic Disorders
    • Kaempferol 3-Glucoside has exhibited effects that could be beneficial in managing metabolic disorders:
      • Obesity: The compound has shown anti-obesity properties.
      • Diabetes: It has demonstrated potential antidiabetic effects.
  • Other Therapeutic Potentials
    • -Liver Protection: Kaempferol 3-Glucoside has shown hepatoprotective effects, potentially benefiting those with liver injuries.
    • -Osteoporosis: The compound has demonstrated anti-osteoporotic properties, which could be beneficial in managing bone loss, particularly in post-menopausal women.
    • -Fibroproliferative Disorders: It may be useful in treating conditions like hypertrophic scars.
Cell Signaling Pathways Affected
 
  • NF-κB Signaling Pathway
    • Kaempferol 3-glucoside inhibits the activation of the NF-κB pathway, which plays a crucial role in inflammation and cancer progression. This inhibition leads to:
      • Reduced expression of pro-inflammatory mediators
      • Decreased cell proliferation and survival of cancer cells
  • PI3K/AKT Pathway
    • The compound attenuates the PI3K/AKT signaling cascade, resulting in:
      • - Inhibition of cell growth and proliferation
      • - Increased apoptosis in cancer cells
  • MAPK Pathway
    • Kaempferol 3-glucoside modulates the MAPK signaling pathway, affecting:
      • - Cell cycle progression
      • - Cellular stress responses
      • - Inflammation
  • JAK/STAT Pathway
    • The flavonoid derivative influences the JAK/STAT signaling pathway, which is involved in:
      • - Immune responses
      • - Cell growth and differentiation
  • Apoptosis Signaling
    • Kaempferol 3-glucoside promotes apoptosis in tumor cells by:
      • - Upregulating pro-apoptotic proteins
      • - Downregulating anti-apoptotic proteins
  • Angiogenesis Signaling
    • The compound inhibits angiogenesis-related pathways by:
      • - Reducing VEGF expression and secretion
      • - Suppressing HIF-1α, a key regulator of VEGF
  • Inflammatory Signaling
    • Kaempferol 3-glucoside exhibits anti-inflammatory effects by:
      • Inhibiting the expression of inflammatory mediators like COX-2 and iNOS
      • Suppressing the activation of inflammatory transcription factors

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