Benarthin (pyroglutamyl peptidase inhibitor)

                                                         



Cat.No: FNK-20323

Size: 2 mg

Storage: -20℃ 

Molecular Weight: 411.415

Purity: >95% (HPLC)

CAS#: 143651-45-0

Molecular Formula: C₁₇H₂₅N₅O₇

Source: Steptomyces sp.

Appearance: Powder

Solubility: Soluble in H₂O, MeOH, DMSO


The chemical structure was confirmed by NMR and HRMS.
 

Appplication

Benarthin was isolated from the fermentation broth of Streptomyces xanthophaerus MJ244-SF1.¹⁾ It inhibited pyroglutamyl peptidase and the binding of benarthin was competitive with substrate (Ki: 1.2 × 10^-6 M).¹⁾ The structure-activity relationship study of synthesized benarthin analogues indicated that the catechol group of benarthin was essential moiety for the inhibition of pyroglutamyl peptidase.^2,3)
 

References

1) Benarthin: a new inhibitor of pyroglutamyl peptidase. I. Taxonomy, production, isolation and biological activities. Aoyagi T, et al. J Antibiot. 1992 45(7) 1079-1083.

2) Benarthin: a new inhibitor of pyroglutamyl peptidase. II. Physico-chemical properties and structure determination. Hatsu M, et al. J Antibiot. 1992 45(7) 1084-1087.

3) Benarthin: a new inhibitor of pyroglutamyl peptidase. III. Synthesis and structure-activity relationships. Hatsu M, et al. J Antibiot. 1992 45(7) 1088-1095.