Anti-SQSTM1/P62 Rabbit Polyclonal Antibody
Product#: SB-GB11239
$560.00
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Anti-SQSTM1/P62 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB11239 |
| Size | ：100 uL |
| Protein full name | ：Sequestosome-1 |
| Synonym | ：SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse SQSTM1 |
| Isotype | ：IgG |
| Predicted MW. | ：48 kDa |
| Observed MW. | ：62 kDa |
| Purity | ：Affinity purification |
| Subcellular location | ：Cytoplasm, Late endosome, Lysosome, Cytoplasmic vesicle, Nucleus, Endoplasmic reticulum |
| Uniprot ID | ：Q13501, Q64337 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| IHS | Human | 1: 500-1: 1000 | gallbladder |
| IF | Human | 1: 500-1: 1000 | gallbladder |
Description
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family . Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery . Involved in midbody ring degradation . May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity).
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Immunohistochemistry analysis of paraffin-embedded human gallbladder using SQSTM1 (GB11239) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded human gallbladder using SQSTM1 (GB11239) at dilution of 1: 1000 |
References
- Yan, J. et alSpermidine-enhanced autophagic flux improves cardiac dysfunction following myocardial infarction by targeting the AMPK/mTOR signalling pathway.British journal of pharmacology176,3126-3142(2019).PMID 31077347Application: IHCIF 8.739
- Guo, C. et alAutophagy promotes malignant migration and invasion via miR-224-5p/BCL2 in pancreatic mucinous cystadenocarcinoma MCC1 cells.Oncology letters20,276(2020).PMID 33029204Application: IHCIF 2.967
Aliases for SQSTM1 Gene
- GeneCards Symbol: SQSTM1 2
- Sequestosome 1 2 3 5
- P60 2 3 4 5
- P62B 2 3 5
- A170 2 3 5
- OSIL 3 4 5
- P62 2 3 5
- Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 KDa 3 4
- EBI3-Associated Protein Of 60 KDa 3 4
- Oxidative Stress Induced Like 2 3
- Ubiquitin-Binding Protein P62 3 4
- Autophagy Receptor P62 2 3
- Sequestosome-1 3 4
- EBIAP 3 4
- PDB3 3 5
- Phosphotyrosine Independent Ligand For The Lck SH2 Domain P62 3
- EBI3-Associated Protein P60 3
- Paget Disease Of Bone 3 2
- FTDALS3 3
- NADGP 3
- DMRV 3
- ZIP3 3
- ORCA 4
