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Anti-Coplanar PCB #118

Product#: FNK-ACPM118AS
$412.85
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Ships in 1-2 Weeks

Anti-Coplanar PCB #118 (Mouse monoclonal antibody) 



General information 

Cat. No. ：FNK-ACPM118AS
Size ：1.0 mL
Antigen   ：PCB #118-KLH conjugate
Host Animal ：Mouse
Isotype ：IgG1
Purification ：This antibody was isolated from culture supernatant of hybridoma by Protein G affinity chromatography.
Purity ：>80% by SDS-PAGE
Concentration ：0.1 mg/mL
Appearance ：Clear liquid
Storage ：Short term, 4℃, Long term, -20℃, Avoid freeze thaw cycles
Shipping Condition  ：Dry Ice
Cross Reactivity
3,3',4,4',-TCB (#77) 17.8
3,4,4',5,-TCB (#81) < 3.0
3,3',4,4',5,-PeCB (#126) < 3.0
3,3',4,4',5,5'-HxTCB (#169) < 0.1
2,3,3',4,4'-PeCB (#105) 2.5
2,3,4,4',5-PeCB (#114) 3.4
2,3',4,4',5-PeCB (#118) 100
2',3,4,4',5-PeCB (#123) < 0.1
2,3,3',4,4',5-HxCB (#156) 7.2
2,3,3',4,4',5'-HxCB (#157) < 0.1
2,3;,4,4',5,5'-HxCB (#167) < 0.1
2,3,3',4,4',5,5'-HpCB (#189) < 0.1
Compounds that show no reaction up to 10 ppm
Acenaphtene, Acenaphtherene, Anthracene, Benzo(a)anthracene, Benzo(a)pyrene, Benzo(b)fluoranthene, Benzo(ghi)perylene, Benzo(k)fluoranthene, Chrysene, Dibenzo(ah)anthracene, Fluoranthene, Hexachlorobenze, Indeno(123cd)pyne, Napthalene, Phennthrene Pyrene, Hexachlorobenze, Biphenyl, 1,2-dichlorobenzene, 3,4-dichloroaniline, 3,4-dichloroanisole, 3,4--dichloronitrobenzene, 3,4-dichlorophenol, 3,4-dichlorotoluene, 1,2,3-trichlorobenzene, 3,4,5-trichloroaniline, 3,4,5-trichlorophenol, 2,3,7,8-TCDD, 2,3,7,8-TCDF
Note: Cross reactivity may be slightly different under each assay condition.
Preservative ：0.1% Sodium azide
Presentation ：Supplied as a liquid in 0.01M Tris, 0.15M NaCl, 0.1% Sodium azide, pH 7.5
 

Human Diseases

  • Linked to chronic inflammatory diseases such as cardiovascular disease, type 2 diabetes, and obesity.
  • Elevated liver enzyme levels and chloracne reported in populations with exposure.
  • Possible carcinogenic effects leading to various cancers.



Cellular Signaling Pathways

  • Involvement of ERK1/2 pathway in cell proliferation during PCB exposure.
  • Association with oxidative stress leading to changes in cellular functions.


Aliases for PCB 118 Gene 

  • 2,3',4,4',5-Pentachlorobiphenyl



References 

  • PCB-118 (Compound).” Exposome, exposome-explorer.iarc.fr/compounds/946. 
  • PCB No. 118.” PCB No. 118 | CAS 31508-00-6 | LGC Standards, www.lgcstandards.com/DE/en/PCB-No-118/p/DRE-C20011800. 
  • Author links open overlay panelDevrim Kaya a b, et al. “A Comparative Evaluation of Anaerobic Dechlorination of PCB-118 and Aroclor 1254 in Sediment Microcosms from Three PCB-Impacted Environments.” Journal of Hazardous Materials, Elsevier, 3 Aug. 2017, www.sciencedirect.com/science/article/abs/pii/S0304389417305940. 
  • Ruggeri, Rosaria, et al. “Polychlorinated Biphenyl Congeners PCB 118 and PCB 126 Induce Upregulation PD-L1 Expression in Human Thyrocytes through Aryl Hydrocarbon Receptor (AHR) Pathways.” Endocrine Abstracts, Bioscientifica, 2 Sept. 2022, www.endocrine-abstracts.org/ea/0084/ea0084ps2-06-56. 

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