Anti-BinCARD Rabbit Polyclonal Antibody
Product#: SB-GB112417
$560.00
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Anti-BinCARD Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112417 |
| Size | ：100 uL |
| Protein full name | ：Caspase recruitment domain-containing protein 19 |
| Synonym | ：Bcl10-interacting CARD protein, BinCARD, Card19, C9orf89, Chromosome 9 open reading frame 89 |
| Immunogen | ：Recombinant protein corresponding to Mouse BinCARD |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Nucleus, Cytoplasm |
| Predicted MW. | ：21 kDa |
| Observed MW. | ：21 kDa |
| Uniprot ID | ：Q9D1I2 |
| Storage | ：Store at -20 ℃ or below for one year. Avoid repeated freeze/thaw cycles. |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse, Rat | 1: 300-1: 600 | kidney |
Description
This gene plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B.
 |
Western blot analysis of BinCARD (GB112417) at dilution of 1: 600 Lane 1: Mouse kidney tissue lysate Lane 2: Rat kidney tissue lysate |
Human Diseases
- Cancer: BinCARD has been implicated in various cancers, including colorectal and breast cancer, where it may promote tumor growth through modulation of signaling pathways.
- Immune Disorders: Alterations in BinCARD expression can affect T cell activation and function, potentially contributing to autoimmune diseases.
- Neurodegenerative Diseases: Dysregulation of mitochondrial proteins like BinCARD may play a role in neurodegenerative conditions.
Cellular Signaling Pathways
- NF-κB Pathway: BinCARD interacts with Bcl10 and can modulate NF-κB activation, although its role appears limited under certain conditions.
- Mitochondrial Signaling: As a mitochondrial protein, BinCARD may influence cellular metabolism and apoptosis through mitochondrial pathways.
- Caspase Activation Pathways: The CARD domain of BinCARD shares homology with other caspase-associated proteins, suggesting potential involvement in apoptosis regulation.
Aliases for CARD19 Gene
- GeneCards Symbol: CARD19 2
- Caspase Recruitment Domain Family Member 19 2 3 5
- BinCARD 2 3 4 5
- C9orf89 3 4 5
- Caspase Recruitment Domain-Containing Protein 19 3 4
- Bcl10-Interacting Protein With CARD 2 3
- Bcl10-Interacting CARD Protein 3 4
- BA370F5.1 2 5
- MGC11115 2 5
- Caspase Recruitment Domain Family, Member 19 2
- Chromosome 9 Open Reading Frame 89 2
References
- Rios, Kariana E, et al. “CARD19, the Protein Formerly Known as Bincard, Is a Mitochondrial Protein That Does Not Regulate BCL10-Dependent NF-ΚB Activation after TCR Engagement.” Cellular Immunology, U.S. National Library of Medicine, Oct. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7484395/.
- Anti-Bincard Antibody.” Abcam, www.abcam.com/en-us/products/primary-antibodies/bincard-antibody-ab201093.
- Author links open overlay panelKariana E. Rios a, et al. “CARD19, the Protein Formerly Known as Bincard, Is a Mitochondrial Protein That Does Not Regulate BCL10-Dependent NF-ΚB Activation after TCR Engagement.” Cellular Immunology, Academic Press, 29 July 2020, www.sciencedirect.com/science/article/abs/pii/S0008874920303397.
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